无溶剂研磨法快速合成3-芳乙烯基-1,5-二酮类化合物的反应研究

Study on the Grinding-Induced Solvent-Free Preparation of 3-Styryl-1,5-diketones

在无溶剂条件下,α,β-不饱和醛与芳香酮在室温下研磨得到2,4-共轭二烯酮,随后,2,4-共轭二烯酮与过量芳香酮在Na OH存在下进一步发生Michael加成反应,快速而高效地合成了3-芳乙烯基-1,5-二酮类化合物.该法与传统的溶液法相比具有不使用溶剂和催化剂,反应条件温和,反应时间短,操作简便等优点.

A convenient procedure for the synthesis of 3-styryl-1,5-dicarbonyl compounds has been developed under solvent-free grinding conditions. α,β-Unsaturated aldehydes react with aromatic ketones to give the corresponding dienone products, then followed by a Michael addition producing 3-styryl-1,5-dicarbonyl compounds in the presence of Na OH at room temperature. The advantages of this procedure are solvent-free, catalyst-free, mild reaction conditions, simple procedure, and short reaction time.