骨疏康胶囊联合依托考昔治疗膝骨关节炎的临床疗效及对炎性因子表达的影响

Effects of Gushukang capsule combined with etoricoxib on clinical efficacy and expression of serum inflammatory cytokines in patients with knee osteoarthritis

目的探讨骨疏康胶囊联合依托考昔治疗膝骨关节炎患者的疗效及对炎性因子白细胞介素1β(IL-1β)、基质金属蛋白酶1,3(MMP-1、MMP-3)及基质金属蛋白酶抑制剂1(TIMP-1)表达的影响。方法选取2011年2月至2013年12月收治的膝骨关节炎患者104例,随机均分为试验组和对照组。试验组使用骨疏康胶囊联合依托考昔进行联合治疗,对照组单独使用依托考昔治疗;以临床疗效、骨关节炎指数(WOMAC)评分、血清各细胞因子浓度、不良反应作为效能指标对比观察。结果治疗后试验组有效率显著高于对照组(P<0.05);与对照组比较,试验组患者疼痛评分、关节僵硬评分、日常活动评分及综合评分显著减小,血清中IL-1β、MMP-1、MMP-3、TIMP-1表达水平显著下调,差异均具有统计学意义(P<0.05);不良事件发生率组间比较差异无统计学意义(P>0.05)。结论骨疏康胶囊联合依托考昔治疗膝骨关节炎效果显著,下调外周血清中IL-1β、MMP-1、MMP-3、TIMP-1的表达水平可能是作用机制之一。

Objective To investigate the effects of Gushukang capsule combined with etoricoxib on clinical efficacy and expression of serum inflammatory cytokines（ IL- 1β,MMP- 1,MMP- 3,TIMP- 1） in patients with knee osteoarthritis. Methods 104 cases of knee osteoarthritis from February 2011 to December 2013 were randomly divided into control group（ etoricoxib treatment） and experimental group（ treated with Gushukang capsule combined with etoricoxib）. The clinical efficacy,WOMAC score,cytokines concentration and adverse events of two groups were compared. Results The efficiency rate of experimental group was significantly higher than control group（ P〈0. 05）. The pain score,anchylosis score,daily activities score and colligation score were smaller in experimental group compared with the control group（ all P〈0. 05）.Compared with the control group,the expression level of inflammatory cytokines（ IL- 1β、MMP- 1、MMP- 3、TIMP- 1） decreased significantly in experimental group（ all P〈0. 05）. However,there was no statistical difference on adverse events in two groups（ P〉0. 05）. Conclusion Gushukang capsule combined with etoricoxib for the treatment of knee osteoarthritis has a significant clinical effect. Reducing the expression levels of IL- 1β,MMP- 1,MMP- 3,TIMP- 1in peripheral serum could be one of the mechanisms.