妊娠期高血压患者外周单个核细胞NF-κB活性及血浆五聚素3的表达的相关性

Pregnancy induced hypertension patients peripheral blood nuclear cells of NF- k B activity and plasma five poly 3 expression correlation

目的探讨妊娠期高血压患者外周单个核细胞核因子κB(NF-κB)活性及血浆五聚素3(PTX3)的表达的相关性。方法选取2012年3月至2014年12月收治的妊娠期高血压疾病患者60例作为观察组,选取同期入院正常晚期妊娠妇女20例作为对照组,分别检测其外周单个核细胞NF-κB和血浆PTX3水平,并进行统计学分析。结果重度子痫前期、轻度子痫前期和妊娠期高血压三组之间NF-κB水平逐渐降低,而PTX3水平逐渐升高,差异有统计学意义(P<0.05)。经Pearson相关分析显示,NF-κB与子痫严重程度呈正相关(r=0.521),而PTX3呈负相关(r=-0.397),差异有统计学意义(P均<0.05);ROC曲线显示,两种指标联合诊断阳性面积0.808,具有诊断意义(P<0.05)。结论妊娠期高血压患者外周单个核细胞NF-κB活性及血浆PTX3的表达呈负相关关系,两者联合检测具有较高的诊断价值。

Objective To investigate the gestational hypertension patients peripheral blood mononuclear cells and plasma NF- k B activity of five poly elements associated with the expression of 3. Methods Patients were selected in our hospital in 2012 March to 2014 year in December. All patients had hypertensive disorder complicating pregnancy. Total 60 cases were considered as the observation group. At the same time,we selected the same admission as a control group of 20 cases of normal late pregnant women. The peripheral mononuclear cells and plasma NF- k B3 level of five poly peptide,and make statistical analysis. Results Severe preeclampsia,mild preeclampsia and gestational hypertension had significant difference among three groups（ P〈0. 05）. NF- κB and preeclampsia severity was positively correlated（ r = 0. 521）,while PTX3 negative correlation（ r =- 0. 397）. The difference was statistically significant（ P〈0. 05）. ROC curve display,two markers for the diagnosis of positive area of 0. 808,and is of diagnostic significance（ P〈0. 05）. Conclusion Pregnancy hypertension patients peripheral blood mononuclear cells and plasma NF- k B activity of five poly 3 expression is negatively correlated,diagnostic value of combined detection of the two has higher.