姜黄素对小鼠帕金森病模型行为学的影响

目的探讨姜黄素对C57BL／6小鼠帕金森病模型行为学的影响及常用行为学测试的比较。方法取30只C57BL／6雄性小鼠随机分成3组：MPTP模型组、姜黄素治疗组和正常对照组；模型组、姜黄素组采用1-甲基．4．苯基1，2，3，6-四氢吡啶（MPTP）腹腔注射造模，正常对照组给予等量0．9％氯化钠注射液腹腔注射。姜黄素组予姜黄素腹腔注射，连续1周。各组小鼠在最后1~P．MPTP或0．9％氯化钠注射液注射后7d予行为学指标检测。结果姜黄素能改善帕金森病模型小鼠行为学中旷场试验、悬挂试验等相关指标（P〈0．05）。对爬杆试验相关指标无明显改善作用。结论姜黄素可改善帕金森病模型小鼠行为学变化。爬杆试验、悬挂试验较易受主观因素影响，旷场试验是更为客观的检测方法。

Objective To observe the curative effect of Curcumin on C57BL/6 mice behavioral manifestation in PD models, and to compare three behavioral tests which are often used in PD models. Methods 30 C57BL/6 mice were randomly divided into three groups as control group, MPTP＋Curcumin group and model group. Mice in MPTP＋Curcumin group and model group received intraperitoneal injection with MPTP to establish PD models, and mice in control group received intraperitoneal injection with the same amount of saline solution for 1 week. Mice in MPTP＋Curcumin group received intraperitoneal injection with Curcumin the same time. Animal behavior detections were carried out on the 7th day after injection. Results Curcumin could improve the general condition and behavioral manifestation in open field test and traction test （ P〈0.05 ） , while the effect on pole test was not significant. Conclusions This study for behaviors of mice in the three groups further confirmed that Curcumin could treat PD model mice behavior to some degree. Subjective factor was inclined to be involved in pole test and traction test. Open field test is a more objective ethological method for MPTP model mice of Parkinson＇s disease.