急性脑梗死患者血清Ⅵ哪柚omentin-1水平及其临床意义

目的探讨急性脑梗死（ACI）患者血清内脏脂肪组织来源的丝氨酸蛋白酶抑制剂（Vaspin）、网膜素-1（Omentin．1）水平变化及其临床意义。方法ACI患者80例（ACI组），根据梗死面积和神经功能缺损程度分为腔隙性脑梗死组、脑梗死组、大面积脑梗死组和轻型组、中型组、重型组，另选择同期门诊健康体检者60例为对照组。采用酶联免疫吸附法（ELISA）检测AcI组和对照组血清Vaspin和Omentin．1水平。结果ACI组Vaspin、Omentin-1水平分别为（0．64±0．07）μg／L、（18．65±2．61）μg／L，均低于对照组的（1．87±0．68）μg／L、（26．73±4．57）μg/L，差异有统计学意义（P〈0．05）。大面积脑梗死和脑梗死组血清Vaspin、Omentin．1水平均明显低于腔隙性脑梗死组（P〈0．05），梗死组血清Vaspin、Omentin-1水平均高于大面积脑梗死组（P〈0．05）。与轻型组比较。中型组、重型组血清Vaspin、Omentin．1水平下降显著，差异有统计学意义（P〈0．05），轻型组血清Vaspin、Omentin-1水平均高于中型组，差异有统计学意义（P〈0．05）。结论ACI组患者血清Vaspin、Omentin-1水平下降，其水平变化可用于判断脑梗死面积和神经功能缺损程度。

Objieetive To study serum visceral adipose tissue-deprived serine proteaseinhibitor （ Vaspin ） and Omentin-1 levels in patients with acute cerebral infarction and its clinical significance. Methods 80 patients with AC1 were selected and divided into different groups according to the size of infarction and clinical neurologic impairment degree score.The serum levels of Vaspin and Omentin-1 were detected by enzyme linked immunosorbent assay.A healthy control group which approximately matched the experimental group included 60 cases. Results Vaspin and Omentin-1 levels in ACI group were （0.64±0.07）μg/L, （18.65_＋2.61） μg/L lower than those in control group{ （1.87±0.68） μg/L, （26.73±4.57） μg/L }, there was significant difference （P〈0.05） . Vaspin and Omentin-1 levels in patients with large area cerebral infarction group and cerebral infarction group were lower than those in patients with lacunar infarction group （ P〈0.05 ） . Vaspin and Omentin-1 levels in patients with cerebral infarction group were higher than those in patients with large area cerebral infarction group （ P〈0.05 ） .Compared with the light group with ACI patients, Vaspin and Omentin-1 levels in the medium group and the heavy group were significantly decreased, there was significant difference （ P〈0.05 ） , Vaspin and Omentin-1 levels in the medium group were higher than those in heavy group, there was significant difference （ P〈0.05 ） . Conclusions Vaspin and Omentin-1 levels in ACI patients were decreased, which can be used to determine cerebral infarction area and neurologic function impairment.