右美托咪定复合亚麻醉剂量氯胺酮对老年结肠癌患者认知能力的影响被引量：2

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摘要目的探讨右美托咪定复合亚麻醉剂量氯胺酮对老年结肠癌患者认知能力的影响。方法老年结肠癌患者81例，分为对照组40例及观察组41例，对照组患者麻醉前静脉注射右美托味定，观察组患者麻醉前静脉注射右美托咪定复合亚麻醉剂量氯胺酮，分别进行简易智力状态检查量表（MMSE）评分、术后苏醒质量评估及血清炎性因子进行检测。结果观察组术后ldMMSE评分较对照组有显著升高（P〈0．05），对照组术后1d较术前1d显著下降（P〈0．05）。术后1d对照组出现POCD3例，观察组出现l例，术后3d对照组出现1例，观察组未出现POCD。观察组自主呼吸恢复时间、意识完全清醒时间、拔管时间及Steward苏醒评分与对照组比较差异无统计学意义（P〉0．05）。两组术后TNF-α、IL-17、hs-CRP与术前比较差异有统计学意义（P〈0．05），观察组术后TNF-α、IL-17、hs-CRP较对照组显著性下降（P〈0．05）。结论右美托咪定复合亚麻醉剂量氯胺酮对老年结肠癌患者认知能力的影响相对较小，这可能与术后炎性因子水平较低有关。

作者叶永科周维钢

机构地区陕西省汉中市中心医院麻醉科

出处《浙江临床医学》 2016年第3期567-568,共2页 Zhejiang Clinical Medical Journal

关键词结肠癌认知能力老年

分类号 R737.905 [医药卫生—肿瘤]

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1Yusoff A R, Aripin Y M, Zuhanis A H. Colon Cancer Recurrence Mimicking Renal Cell Carcinoma. Med J Malaysia,2014, 69(6): 286-287.
2Peng L, Xu L, Ouyang W. Role of" peripheral inflammatory markers in postoperative cognitive dysfunction (POCD): a meta-analysis. PLoS One,2013, 8(11): e79624.
3Decrane S K, Sands L P, Young K M, et al. Impact of missing data on analysis of postoperative cognitive decline (POCD). Appl Nurs Res. 2013, 26(2): 71-75.
4宁玉洁,王溪,郭雄.含硒蛋白在人类结肠癌组织中的表达[J].国外医学（医学地理分册）,2013,34(1):27-29. 被引量：7
5Wu Y, Wang J, Wu A, et al. Do fluctuations in endogenous melatonin levels predict the occurrence of postoperative cognitive dysfunction (POCD). IntJ Neurosci, 2014, 124(11): 787-791.
6Fan Y X, Liu F F, Jia M, et al. Comparison of restrictive and liberal transfusion strategy on postoperative delirium in aged patients following total hip replacement: a preliminary study. Arch Gerontol Geriatr, 2014, 59(1): 181-185.
7Song H K, von Heymann C, Jespersen C M, et al. Safe apphcation of a restrictive transfusion protocol in moderate-risk patients undergoing cardiac operations. Ann Thorac Surg,2014, 97(5): 1630-1635.
8Ibacache M E, Munoz H R, Fuentes R, et al. Dexmedetomidine- ketamine combination and caudal block for superficial lower abdominal and genital surgery in children. Paediatr Anaesth,2015, 25(5): 499-505.
9Kim B W, Peskin R M. Dexmedetomidine, ketamine, and midazolam for oral rehabilitation: a case report. Anesth Prog,2015, 62(1): 25-30.
10IzerJ M, Whitcomb TL, Wilson R P. Atipamezole reverses ketamine- dexmedetomidin& anesthesia without altering the antinociceptive effects fbutrphanl and buprenorphine in female C57BL/6J mice. J Am Asso Lab Anim Sci,2014, 53(6): 675-683.

二级参考文献10

1Yagblu V, Arthur JR, Babayeva SN, et al. Expression of selenium-containing proteins in human colon carcinoma tissue[J]. Anticancer Research, 2011,31(9):2693-2698.
2Hawk ET, Levin B. Colorectal cancer prevention[J]. Clin Oncol, 2005, 23(2): 378-391.
3Rayman MP. Selenium in cancer prevention: a review of the evidence and mechanism of action[J]. Proc Nutr Soc, 2005,64 (4) :527-542.
4Irons R, Tsuji PA, Carlson BA, et al. Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells[J]. CancerPrev Res (Phila) ,2010, 3(5) : 630-639.
5Crosley LK, Meplan C, Nicol F, et al. Differential regulation of expression of cytosolic and mitoehondrial thioredoxin reductase in rat liver and kidney[J]. Arch Biochem Biophys,2007, 459(2): 178-188.
6Reeves MA, Hoffmann PR. The human selenoproteome: recent insights into functions and regulation[J]. Cell Mol Life Sci, 2009, 66(15): 2457-2478.
7Lu J, Holmgren A. Selenoproteins[J]. J Biol Chem, 2009, 284 (2) : 723-727.
8Yamasaki T, Tahara K, Takano S, et al. Mechanism of plasma glutathione peroxidase production in bovine adipocytes[J]. Cell Tissue Res, 2006, 326(1):139-147.
9Murawaki Y, Tsuchiya H, Kanbe T, et al. Aberrant expression of selenoproteins in the progression of colorectal cancer[J]. Cancer Lett, 2008, 259(2): 218-230.
10刘芳印.硒的生物酶与抑癌机制研究进展[J].右江医学院学报,2008,36(5):620-622.