天然产物Longistylines A的全合成与抑菌活性研究

Total synthesis and and bacteriostatic activity of nature product Longistylines A

以廉价的3,5-二羟基苯甲醇为起始原料,经羟基保护、溴代、Arbuzor重排、Wittig-Horner反应、脱甲基保护及C-异戊烯基取代等步骤,首次以较高产率完成了天然产物化合物Longistylines A的全合成,关键步骤为Wittig-Horner反应以及C-异戊烯基化反应,所有新化合物的结构都经过~1 H NMR,IR,MS确认.抑菌活性研究表明,该化合物对枯草芽孢杆菌（Bacillus subtilis ATCC 11562）、金黄色葡萄球菌（Staphylococcus aureus ATCC 6538）、溶血葡萄球菌（Staphylococcus haemolyticus ATCC 29970）均有良好的抑制作用.

The total synthesis of natural product Longistylines A was first achieved from cheap material,3,5-dihydroxybenzyl alcohol.The synthetic procedure was in the sequence of protection of hydroxyl group,bromination,Arbuzor rearrangement,WittigHorner reaction,demethylation and C-prenylation.Wittig-Horner reaction and C-prenylation were key steps.All structures of new compounds were confirmed by IR,~1 H NMR and MS.And bioassay results indicated the newly synthesized compound possessed good inhibitory effect against Bacillus subtilis,Staphylococcus aureus and Staphylococcus haemolyticus.