针灸治疗卵巢早衰疗效Meta分析

Meta Analysis the Effect of Acupuncture in Treating Premature Ovarian Failure

目的:系统评价针灸方法治疗卵巢早衰的临床疗效。方法:采用循证医学(Cochrane)系统评价法,检索Pub Med、中国知网(CNKI)、万方数据库(Wan Fang Data)、维普数据库(VIP)等数据库,检索时间从建库到2015年9月,针灸治疗卵巢早衰的随机对照试验均可纳入,对纳入文献的质量逐一进行评价,提取相关有效数据,采用Rev Man5.2软件对其数据进行Meta分析。结果:共纳入9篇文献,卵巢早衰患者共计719例,进行Meta分析。Meta分析结果显示:治疗后,针灸组与西药组比较,有效率的差异显著(P<0.01);促卵泡生成素(FSH)在治疗后的改善情况,雌二醇(E2)水平改善情况,均是针灸组要优于西药组,差异显著(P<0.05);所纳入Meta分析的文章中4篇提到结局指标黄体生成素(LH),差异不明显(P>0.05)。结论:在采用针灸方法治疗卵巢早衰中,临床观察后收集数据并分析有效率和血清激素水平的改善情况,针灸疗效要比西药疗效好。因为针灸难以实施双盲,纳入文献质量存在有低质量文献,尚期待高质量的试验提供高质量的证据。

Objective： To assess the therapeutic effect of acupuncture and moxibustion for premature ovar- ian failure（POF）. Methods：Based on Cochrance system assessment methods,the search engine PubMed,CNKI and databases（till Sept,2015）including WanFang data and VIP database were used to retrieve.The randomized controlled trial of treating POF with the method of acupunture and moxibustion were inserted, the quality of adopted literature were evaluated one by one and valid data were extracted.Meta-analysis was conducted with the assistance of Rev- ManS.2 software. Results：Nine randomized controlled trials （RCTs） involving 719 patients in all with POF were on me- ta-analysis. Results of meta-analysis indicated： After treatment, there was statistical＇difference between acupuncture and Western medicine groups on effective rate （P〈0.01）The results of Follicle-stimulating Hormone（FSH） and estrogen （E2） after therapy were better in the acupunctnre group than those in the Western medicine group,which had statisti- cal significance （P〈0.05）.Four of the 9 literatures referred to reported outcomes of Luteinizing -hormone （LH） and their differences had no statistical significance. Conclusions：During the treatment to POF,by observing clinically and analyz- ing the improvement of clinical efficacy and the level of serum hormone,the clinical efficacy of the method of acupunc- ture and moxibustion is better than that of the method of Western medicine.Since it＇ s difficult to achieve double-blind in the treatment of acupuncture and moxibustion and adopted literatures include some of low quality,so it remains to look forward to that high-quality experiments will provide hizh-Qualitv evidence.