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Mesenchymal stem cells require the peripheral immune system for immunomodulating effects in animal models of multiple sclerosis 被引量：5

Mesenchymal stem cells require the peripheral immune system for immunomodulating effects in animal models of multiple sclerosis
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摘要 Multiple sclerosis（MS）is a chronic inflammatory disease of the central nervous system（CNS）that affects oligodendrocytes and myelin.Loss of myelin leads to progressive axonal damage and neuronal death resulting in neurodenegeration and functional disability.Several inflammatory factors influence the development of this neurological disorder. Multiple sclerosis（MS）is a chronic inflammatory disease of the central nervous system（CNS）that affects oligodendrocytes and myelin.Loss of myelin leads to progressive axonal damage and neuronal death resulting in neurodenegeration and functional disability.Several inflammatory factors influence the development of this neurological disorder.
作者 Laura Salinas Tejedor Thomas Skripuletz Martin Stangel Viktoria Gudi
机构地区 Clinical Neuroimmunology and Neurochemistry Center for Systems Neuroscience
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第1期90-91,共2页 中国神经再生研究（英文版）
基金 This research on MSC was supported by the German Research Foundation(DFG FOR 1103 TP1b STA 518/4-1)
关键词 disability migrate myelin axonal neuronal neurological progressive affects interleukin amyotrophic disability migrate myelin axonal neuronal neurological progressive affects interleukin amyotrophic
分类号 R744.51 [医药卫生—神经病学与精神病学] R-332 [医药卫生]
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参考文献13

  • 1Al lumah MA, Abumaree MH (2012) The immunomodulatory and neuroprotective effects of mesenchymal stem cells (MSCs) in experimental autoimmune encephalomyelitis (EAE): a model of multiple sclerosis (MS). Inr J Mol Sci 13:9298-9331.
  • 2Dulamea A (2015) Mesenchymal stem cells in multiple sclerosis - translation to clinical trials. J Med Life 8:24-27.
  • 3Franklin RJ (2015) Regenerative medicines for remyelination: from aspiration to reality. Cell Stem Cell 16:576-577.
  • 4Harris VK, Yan QJ, Vyshkina T, Sahabi S, Liu X, Sadiq SA (2012) Clinical and pathological effects of intrathecal injection of mesenchymal stem cell-derived neural progenitors in an experimental model of multiple sclerosis. J Neurol Sci 313:167-177.
  • 5Kassis I, Grigoriadis N, Gowda-Kurkalli B, Mizrachi-Kol R, Ben-Hur T, Slavin S, Abramsky 0, Karussis D (2008) Neuroprotection and irnmunornodulation with mesenchymal stem cells in chronic experimental autoimmune encephalomyelitis. Arch NeuroI65:753-761.
  • 6Mahad DH, Trapp BD, Lassmann H (2015) Pathological mechanisms in progressive multiple sclerosis. Lancet Neurol 14: 183-193.
  • 7Nessler J, Benardais K, Gudi V, Hoffmann A, Salinas Tejedor L, JanBen S, Prajeeth CK, Baumgartner W, Kavelaars A, Heijnen C), van Velthoven C, Hansmann F, Skripuletz T, Stangel M (2013) Effects of murine and human bone marrow-derived mesenchymal stem cells on cuprizone induced demyelination. PLoS One 8:e69795.
  • 8Odoardi F, Sie C, Streyl K, Ulaganathan VK, Schlager C, Lodygin D, Heckelsmiller K, Nietfeld W, Ellwart J, Klinkert WE, Lottaz C, Nosov M, Brinkmann V, Spang R, Lehrach H, Vingron M, Wekerle H, Flugel-Koch C, Fliigel A (2012) T cells become licensed in the lung to enter the central nervous system. Nature 488:675-679.
  • 9Robinson AP, Harp CT, Noronha A, Miller SD (2014) The experimental autoimmune encephalomyelitis (EM) model of MS: utility for understanding disease pathophysiology and treatment. Handb Clin NeuroI122:173-189.
  • 10Salinas Tejedor L, Berner G, Jacobsen K, Gudi V, Jungwirth N, Hansmann F, Gingele 5, Prajeet.h CK, Baumgartner W, Hoffmann A, Skripuletz T, Stangel M (2015) Mesenchymal stem cells do not exert direct beneficial effects on CNS remyelination in the absence of the peripheral immune system. Brain Behav lrnrnun 50: 155-165.

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Neural Regeneration Research
2016年 第1期

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