2型糖尿病并发肾病危险因素分析

Analysis on risk factors of complicated diabetic nephropathy in type 2 diabetes mellitus

目的:分析2型糖尿病肾病(DN)的危险因素,为早期预防DN提供理论依据。方法:回顾性纳入2013年12月-2014年12月常州市第二人民医院内分泌科2型糖尿病住院患者249例,按美国糖尿病协会(ADA)2012推荐标准,将尿微量白蛋白/肌酐(UAlb/CR)≥30.0 mg/g的54例患者作为DN组,UAlb/CR<30.0 mg/g的195例作为非DN组。收集患者的临床资料,并做比较分析。结果:2组患者年龄,糖化血红蛋白(Hb A1c),血肌酐(SCr),总胆固醇(TC),甘油三脂(TG),高密度脂蛋白(HDL),低密度脂蛋白(LDL),糖尿病(DM)病程,家族史,收缩压(SBP),舒张压(DBP)比较,差异均有统计学意义(P值均小于0.05)。Logistic回归分析表明SCr,HDL,LDL,SBP,DBP与DN的发生有关。结论:DN的发生与遗传因素、环境因素、高血糖、血脂异常、高血压有关,重视DN危险因素的监测对早期预防DN意义重大。

Objective： To identify the risk factors of type 2 diabetes mellitus complicated with diabetic nephropathy（ DN）,and provide theoretical basis for early prevention of DN. Methods： 249 cases of type 2 diabetic inpatients in Changzhou Second People＇s Hospital between December 2013 and December 2014 were retrospectively analyzed. Based on the USA Diabetes Association（ ADA） 2012 recommendation,54 cases were classified as a DN group（ UAlb / CR ≥ 30. 0 mg / g）,while another 195 cases as a non-DN group（ UAlb/CR 30. 0 mg/g）. Clinical data were collected and comparative analysis was conducted. Results： Differences were detected between the two groups in terms of age,Hb A1 c,SCr,TC,TG,HDL,LDL,duration of DM,family history,SBP and DBP,which were statistically significant（ P〈0. 05）. Logistic regression analysis showed that SCr,HDL,LDL,SBP,DBP were relevant to the onset of DN.Conclusion： Genetic factors,environment,high blood glucose,dyslipidemia,and hypertension have been found to be related with the occurrence of DN. It is significant for early prevention of the DN to monitor the risk factors of DN.