甘草酸制剂治疗病毒性肝炎疗效观察

Clinical Observation of 3 Kinds of Glycyrrhizic Acid Preparations in Treatment of Viral Hepatitis with Hyperbilirubinemia

目的观察复方甘草酸苷、甘草酸二铵、异甘草酸镁3种甘草酸制剂治疗病毒性肝炎合并高胆红素血症的临床疗效。方法将120例病毒性肝炎合并高胆红素血症患者随机分为A、B、C三组各40例,均接受常规治疗。A组患者加用甘草酸二铵注射液治疗;B组患者加用复方甘草酸苷注射液治疗;C组患者加用异甘草酸镁治疗。均治疗2个月。结果 C组患者肝功能指标及血清纤维化指标均明显低于A、B两组,而B组各项指标又明显低于A组,且组间差异具有统计学意义(P<0.05);C组治疗有效率97.50%明显高于A组和B组,而B治疗有效率80.00%又明显高于A组,组间差异具有统计学意义(P<0.05)。结论异甘草酸镁在病毒性肝炎合并胆红素血症患者治疗中的应用效果要优于甘草酸二胺及复方甘草酸苷,可以作为临床首选。

Objective To summarize the clinical effects of compound glycyrrhizin,diammonium glycyrrhizinate,magnesium isoglycyrrhizinate in treatment of viral hepatitis with hyperbilirnemia. Methods 120 patients with viral hepatitis with high bilirubin level were randomly divided into A,B,C groups,40 cases in each group with routine treatment. Group A received diammonium glyoyrrhizinate,group B recived compound glycyrrhizin glucoside injection,group C received magnesium isoglycy- irhizinate on the basis of routine treatment. after 2months of treatment,observe the effects of the three groups. Results The liver function index and serum fibrosis index of group C were significantly lower than group A,group B,each index was significantly lower than that of group A and group B,and the differences between groups were with statistical significance（ P〈0. 05）; the effective rate of group C was 97. 50%,obviously higher than that of group A and group B,the effective rate of group B was effectiveness 80. 00%,obviously higher than that of group A,differences between groups were with statistical significance（ P〈0. 05）. Conclusion The curative effect of magnesium isoglycyrrhizinate in treatment of viral hepatitis with hyperbilirubinemia is superior to compound glycyrrhizin and diammoniam glyoyrrhizinale,can be used as a clinical choice.