基于动态建构化学的自愈合水凝胶及其在生物医学领域的应用展望

Self-healing Hydrogels Based on Constitutional Dynamic Chemistry and Their Potential Biomedical Applications

自愈合水凝胶与传统水凝胶相比,经受力破坏后仍可恢复其结构和功能,具有自我修复损伤的特点,是近年来备受关注的一种智能软材料.动态建构化学概念的引入,极大地促进了多响应性动态自愈合水凝胶的发展.本文综述了近年来基于动态建构化学合成自愈合水凝胶的方法,包括多重氢键作用、疏水相互作用、亚胺键、酰腙键等,并分析探讨了影响凝胶自愈合性能的因素及其在生物医学领域的潜在应用,还对其未来的发展进行了展望.

Compared with traditional hydrogels,self-healing hydrogels can restore their structures and functionalities automatically after damage,which have caused extensive concern as ＂smart＂soft materials in recent years. The rapid development of multi-responsive dynamic self-healing hydrogels has been achieved by introducing the concept of constitutional dynamic chemistry in this field. In this review,the current strategies for synthesizing self-healing hydrogels based on the concept of constitutional dynamic chemistry are introduced,including multiple hydrogen bonds,hydrophobic interactions,imine bonds,acylhydrazone bonds,etc.Furthermore,the key factors affecting self-healing properties and the applications of self-healing hydrogels in biomedicine are discussed,as well as the challenge and future development of self-healing hydrogels are proposed.