期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

谷胱甘肽转移酶基因多态性与妇科恶性肿瘤易感性和预后的相关性研究进展 被引量：1

下载PDF
导出
摘要 谷胱甘肽转移酶(GST)是体内重要的Ⅱ相代谢酶,GST在人群中呈多态性分布,基因多态性导致酶活性降低或丧失。研究显示GST基因多态性不仅与妇科多种恶性肿瘤的易感性有关,而且会影响化疗药物对肿瘤的疗效,影响患者的预后,且结果存在差异。本文将重点阐述删基因多态性、GST基因分型方法的进展及GST与妇科肿瘤易感性和预后的关系。
作者 黄神姣 陈敦金 谭鹰 夏华安 You MJ
机构地区 广州市妇女儿童医疗中心妇产科 广州医科大学第三附属医院妇产科 美国得州大学安德森癌症中心
出处 《癌变．畸变．突变》 CAS CSCD 2016年第1期73-76,共4页 Carcinogenesis,Teratogenesis & Mutagenesis
基金 广州医科大学留学回国人员启动基金资助(2011C45) 广东省科技计划项目(2015A020211001)
关键词 谷胱甘肽转移酶 多态性 恶性肿瘤 易感性 预后
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献40

  • 1Mellwain CC, Townsend DM, Tew KD. Glutathione S-transferase polymorphisms: cancer incidence and therapy[J]. Oncogene, 2006, 25(11): 1639-1648.
  • 2Chen HC, Cao YF, Hu WX, et al. Genetic polymorphisms of phase II metabolic enzymes and lung cancer susceptibility in a population of Central South China[J]. Dis Markers, 2006, 22(3): 141-152.
  • 3Singh H, Sachan R, Devi S, et al. Association of GSTM1, GSTT1, and GSTM3 gene polymorphisms and susceptibility to cervical cancer in a North Indian population[J]. Am J Obstet Gynecol, 2008, 198(3): 303-306.
  • 4Townsend DM, Tew KD. The role of glutathione-S transferase in anti- cancerdrugresistance[J].Oncogene, 2003, 22: 7369-7375.
  • 5Di Pietro G, Magno LA, Rios-Santos F. Glutathione S-transferases: an overview in cancer research[J]. Expert Opin Drug Metah Toxicol,2010, 6(2): 153-170.
  • 6Xu S, Wang Y, Roe B, et al. Characterization of the human class Mu glutathione S-transferase gene cluster and the GSTM1 deletion[J]. J Biol Chem, 1998, 273(6): 3517-3527.
  • 7Smith CM, Kelsey KT, Wiencke JK, et al. Inherited g]utathione-S- transferase deficiency is a risk factor for pulmonary asbestosis[J]. Cancer Epidemiol Biomarkers Prey, 1994, 3(6): 471-477.
  • 8Parl F. A need for true GSTM1 and GSTF1 genotyping[J]. Cancer Epidemiol Biomarkers Prey, 2009, 18(10): 2793.
  • 9Roodi N, Dupont WD, Moore JH. et al. Association of homozygous wild-type glutathione S-transferase M1 genotype with increased breast eancerrisk[J]. Cancer Res, 2004, 64(4): 1233-1236.
  • 10Sprenger R, Schlagenhaufer R, Kerb R. Characterization of the glutathione S-transferase GSTY1 deletion : discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype phenotype correlation[J]. Pharmacogenetics, 2000, 10: 557-65.

二级参考文献28

  • 1武守山,邢朝斌.汉族人群谷胱甘肽-S-转移酶M1、T1基因多态性分析[J].中国优生与遗传杂志,2005,13(3):15-16. 被引量：5
  • 2Xiao-MeiLu,Yue-MingZhang,Ren-YongLin,ArziGul,XingWang,Ya-LouZhang,YanZhang,YanWang,HaoWen.Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in Xinjiang, China[J].World Journal of Gastroenterology,2005,11(24):3651-3654. 被引量：15
  • 3Norppa H, Hirvonen A, Jarventaus H, et al. Role of GSTT1 and GSTM1 genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes [ J ]. Carcinogenesis, 1995,16 ( 6 ) : 1261-1264.
  • 4Cavalieri E,Chakravarti D, Guttenplan J, et al. Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention [ J ]. Biochim Biophys Acta,2006,1766 ( 1 ) :63-78.
  • 5Richard CS, Monica AS, Sudarshan R, et al. Glutathione Stransferase family of enzymes [ J 1. Respiration Physiology,2001, 128: 3-11.
  • 6Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells[ J]. Nucleic Acid Res,1988,16(3) :1215.
  • 7Legro RS, Kunselman AR, Miler SA, et al. Role of androgens in the growth of endometrial carcinoma: an in vivo animal model [ J ]. Am J Obstet Gynecol, 2001,184 ( 3 ) : 303-308.
  • 8Joseph T,Chacko P,Wesley R, et al. Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: Associations with tumor progression, age and human papillomavirus infection[J]. Gynecol Oncol, 2006, 101 ( 3 ) : 411-417.
  • 9Joseph T,Chacko P,Wesley R,et al. Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: Associations with tumor progression, age and human papillomavirus infection [ J ]. Gynecol Oncol, 2006, 101 ( 3 ) : 411417.
  • 10郑兴征,杨安强,潘晓琳,郑莉莉,周秋媛,李新敏,王晓凌,严丽华,李洪安.p53 Arg72Pro多态性与新疆维吾尔族和汉族妇女宫颈癌发生的相关性[J].中华病理学杂志,2007,36(8):511-515. 被引量：6

共引文献22

同被引文献10

引证文献1

二级引证文献4

癌变．畸变．突变
2016年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部