单用左氧氟沙星及其联用宁泌泰胶囊治疗慢性前列腺炎的药物经济学评价

Pharmacoeconomic Evaluation on Ningmitai Capsule Combined with Levofloxacin Therapy for Chronic Prostatitis

目的:比较单用左氧氟沙星与其和宁泌泰联合使用治疗慢性前列腺炎的临床有效率,并对其做经济学评价。方法:检索需要的数据库,对符合纳入标准的国产与进口左氧氟沙星治疗细菌感染的文献进行Meta分析,以临床总有效率作为指标,用成本-效果法进行药物经济学评价。结果:共检索到6个RCT研究,包括1383名患者;Meta分析显示,联合用药与单用左氧氟沙星的临床有效率比较有统计学意义,合并OR=1.28,其95%CI为(1.21,1.36);经济学评价结果显示,联合用药成本更高。结论:联合用药提高了临床有效率,减少了不良反应和耐药性,虽然治疗成本有所增加,但考虑其间接收益,联合用药依然有其合理性。

ObjectiveTo compare the difference of the clinical efficacy therapies for chronic prostatitis be-tween levofloxacin and Ningmitai Capsule combined with levofloxacin, and evaluate their pharmacoeconomics.MethodsConducted database retrieval for meta analysis about the literatures which met criteria of domesticand imported levofloxacin to treat bacterial infections. Totally took clinical efficacy rate as index, to evaluatepharmacoeconomics with the cost-effectiveness method.ResultsThe 6 random control trials（RCT） studieswere retrieved, including 1383 patients; meta analysis showed that there was statistical significance as comparedthe combination of levofloxacin and Ningmitai Capsule, with single use of levofloxacin, merger OR = 1.28, 95%CI（1.21, 1.21）. The economics evaluation results showed that the costs of combination treatment were higherthan the single use of levofloxacin.ConclusionThe combination of the drugs improves the clinical efficiency,reduces the adverse reactions and drug resistance. Although the treatment costs were increased, the drug combi-nation still has its rationality considering its indirect value.