白番红花球茎醇提取物的镇痛抗炎作用研究

Study on analgesic and anti- inflammation effects of the compounds isolated from Corm of Crocus Alatavicus with ethanol

目的:探讨白番红花球茎醇提取物的镇痛抗炎作用。方法:采用小鼠醋酸扭体法观察白番红花球茎醇提取物的镇痛作用;采用二甲苯致小鼠耳廓肿胀法观察白番红花球茎醇提取物的抗炎作用。结果:白番红花球茎醇提取物高、中、低剂量组能显著减少醋酸所致小鼠的扭体次数,与空白对照组比较,差异均有统计学意义(P<0.05);白番红花球茎醇提取物高剂量组能显著抑制二甲苯所致的小鼠耳廓肿胀度,与空白对照组比较,差异有统计学意义(P<0.05)。结论:白番红花球茎醇提取物有明显的镇痛作用,高剂量有一定的抗炎作用。

Objective To investigate analgesic activities and anti - inflammatory of the compounds isolated from Corm of Crocus Alatavicus with ethanol. Methods Analgesic effects of Corm of Crocus Alatavicus were investigated by acetic acid writhing test in mice ; Anti - inflammatory effects were investigated by xylene - induced auricle swelling in mice. Results The results showed that the high, middle and low dosages of Corm of Crocus Alatavicus could markedly reduce the twisting number compared with blank control group, they showed a strong difference （P 〈 0. 05） ; and the high dosages of Corm of Crocus Alatavicus could relieve swollen auricle of mice induced by xylene, the result showed a strong difference compared with blank control group （P 〈 0.05 ）. Conclusion The results showed that Corm of Crocus Alatavicus have remarkable analgesic and high dosages of Corm of Crocus Alatavicus have anti - inflammato- ry effects by different administrations.