摘要
微生物产生的次级代谢产物为微生物药物的重要来源,大多由生物合成基因簇编码的酶蛋白催化合成。研究微生物药物生物合成基因簇的进化有助于了解微生物药物结构多样性的遗传基础以及其生理生态学意义,对新化合物挖掘和新药发现具有指导作用。本文以代表性的聚酮类化合物为切入点,以负责合成聚酮化合物骨架的聚酮合酶(PKS)为例,综述Ⅰ型PKS的进化起源,基因簇在不同微生物之间的传递及同一种微生物内部的基因簇进化机制。
The microbes can produce a series of secondary metabolites with important biological activity that have been a main source of microbial medicines. The genes being responsible for microbial medicine biosynthesis usually distribute linearly in genome and accumulate in one biosynthetic gene clusters, which is formed in long historical evolution and still in evolutional procedure. The studies on gene clusters evolution may facilitate the understanding of the genetic rules for microbial medicine structure diversity and physiological ecology significance. Such knowledge is also useful for seeking new compound and new drug discovery. This review focuses on the evolution of microbial medicine biosynthesis gene clusters, especially for type I polyketide synthase （PKS） including the evolutional origin of PKS, the delivery of PKS between bacteria and intra-genomic evolution mechanism.
出处
《世界临床药物》
CAS
2016年第2期129-134,共6页
World Clinical Drug
基金
上海市自然科学基因(编号:15zr1440300)
