精液加德纳菌检测在体外受精-胚胎移植中的临床意义

Clinical Application of the Semen Gardnerella Vaginalis Test in IVF-ET

长期以来辅助生殖技术(ART)的成功率受多方面因素的影响,其中微生物感染可能是其中之一。在男性中,阴道加德纳菌(Gardnerella vaginalis,GV)感染可以引起泌尿生殖道感染、肾盂肾炎、脑炎、肝脓疡和肺脓肿等疾病;在女性中可引起阴道炎、不孕、流产和早产等。近年不明原因的男性不育患者精液中GV的检出率明显高于正常男性。但目前关于GV与男性不育及其在体外受精-胚胎移植(IVF-ET)的相关研究较少,而且GV感染对男性精液质量和对胚胎发育影响的结论尚存在争议,GV导致男性不育的致病机制仍不清楚。综述GV在男性中的流行病学、可能导致不育的机制、与胚胎发育的关系及其在ART中的临床意义。

The success rate of assisted reproductive technology（ART） was affected by many factors,including microorganism infection. In males, Gardnerella vaginalis（GV） infection can cause urinary tract infection,pyelonephritis, encephalitis, liver abscess, lung abscess and other diseases. And in women, GV infection can cause vaginitis, infertility, abortion and others. In recent years, the detection rate of positive GV in male infertility patients with unknown causes was significantly higher than that in normal males. The study on the relationship between GV infection and male infertility, and the outcomes of in vitro fertilization-embryo transfer（IVF-ET）, was limited so far. What effect of GV infection on the sperm quality and the embryo development, and the pathogenic mechanism of male infertility related to GV infection, is still not clear. The GV epidemiology in men, the possible mechanism of infertility related to GV infection, the effect of GV on the embryo development and the clinical application of semen GV test in ART were reviewed in this paper.