血脂、脂蛋白相关磷脂酶A_2与糖尿病视网膜病变关系的研究进展

Research progress of the relationship between blood lipid,lipoprotein-associated phospholipase A_2 and diabetic retinopathy

糖尿病视网膜病变(DR)是导致不可逆性盲的重要原因之一,DR发病与动脉粥样硬化密切相关,其治疗干预靶点成为当今研究的热点。血浆脂蛋白相关磷脂酶A_2(Lp-PLA_2)是一种新型的动脉粥样硬化性炎性标志物,与血脂密切相关,由Lp-PLA_2所引起的慢性炎症反应与脂质代谢紊乱共同作用导致了动脉粥样硬化的发生。目前,关于Lp-PLA_2的认识还不完善,仍需要进行大量的实验研究以明确Lp-PLA_2与DR发生、发展的关系及其致病机制。

Diabetic retinopathy（DR） is one of the major causes of irreversible blindness,and the onset of DR is closely linked to atherosclerosis.The therapeutic intervention targets for DR has become a research hotspot.As one of novel markers of inflammation in atherosclerosis,lipoprotein-associated phospholipase A2（Lp-PLA2） is closely related to blood lipid level.The chronic inflammatory reaction caused by Lp-PLA2 combined with lipid metabolism disorders lead to the occurrence of atherosclerosis.Currently,understanding of the Lp-PLA2 is still not perfect,still requires extensive study to make clear that the relationship between Lp-PLA2 and the occurrence and development of DR as well as its pathogenetic mechanism.