普罗布考联合阿托伐他汀在急性脑梗死患者中的应用效果

Effect of atorvastatin combined with atorvastatin in patients with acute cerebral infarction

目的观察急性脑梗死患者应用普罗布考联合阿托伐他汀的疗效及复发情况。方法收集2010年1月~2012年11月于辽宁省金秋医院入院的初次患前循环急性脑梗死且经颈动脉超声检查存在颈动脉粥样硬化不稳定性斑块患者120例,将其随机分为观察组及对照组。观察组给予普罗布考联合阿托伐他汀治疗;对照组给予单纯阿托伐他汀治疗。观察两组患者治疗后血脂水平、颈动脉斑块检出率、斑块积分情况及脑梗死复发情况。结果两组治疗后血脂水平（TG、CHOL、LDL-C）下降,较治疗前差异有统计学意义（P〈0.05）,两组治疗后1年与2年的TG、CHOL、HDL-C、LDL-C水平比较差异无统计学意义（P〉0.05）;两组治疗后颈动脉不稳定斑块检出率降低,不稳定斑块积分降低,观察组低于对照组,差异有统计学意义（P〈0.05）;治疗后2年观察组脑梗死复发率低于对照组,差异有统计学意义（P〈0.05）。结论急性脑梗死患者如存在颈动脉不稳定性斑块,长期应用普罗布考联合阿托伐他汀治疗有利于转归不稳定斑块、降低脑梗死复发率。

Objective To observe the therapeutic effect and recurrence with combined therapy of probucol with atorvastatin for patients with acute cerebral infarction. Methods From January 2010 to November 2012,120 patients admitted in the Jinqiu Hospital of Liaoning Province by reason of acute anterior circulation infarction with vulnerable plaque by carotid ultrasound at the first time were randomly assigned to observation group and control group.The observation group was treated with probucol combined with atorvastatin.At the same time the control group was only treated with atorvastatin.The serum level of lipid,detection rates of carotid plaque,scores of plaque and recurrence of cerebral infarction were observed. Results After treatment,the levels of TG,CHOL and LDL-C between two groups was significantly decreased respectively,with statistical difference（P〈0.05）.Compared with the control group,there was no significant differences for the levels of TG,CHOL,LDL-C and HDL-C after treatment for one year and two years（P〈0.05）.After treatment both detection rates and scores of carotid vulnerable plaque for the observation group was significantly decreased than that of the control group respectively,with statistical difference（P〈0.05）.The recurrence of cerebral infarction was decreased after treatment for two years compared with the control group,with statistical difference（P〈0.05）. Conclusion For those patients with acute cerebral infarction who are detected with carotid vulnerable plaque,long-term therapy of probucol combined with atorvastatinis contribute to reverse vulnerable plaque and reduce recurrence of cerebral infarction.