血糖血压及体质量与胰腺癌发生的相关性研究

Correlation of blood glucose, blood pressure and body weight with pancreatic cancer

目的探讨血糖、血压及体质量与胰腺癌发生的相关性。方法选取2011年1月至2013年12月在我院住院确诊的胰腺癌患者110例为观察组，另选同期住院同年龄段的非肿瘤类疾病患者i10例为对照组，分析两组患者中糖尿病、高血压和体质指数（BMI）增高患者的比例。结果观察组检出糖尿病患者明显多于对照组[32例（29．1％）比16例（14．6％），P〈0．05]，其中糖尿病病程〈2年、2～5年及〉5～lO年的胰腺癌患者比例均显著高于对照组，差异有统计学意义（P〈0．05）；观察组BMI增高者显著多于对照组[27（24．6％）比12例（10．9％），P〈0．053，其中糖尿病合并BMI增高及高血压合并BMI增高的比例均显著高于对照组[19例（17．3％）比3例（2．7％）、12例（10．9％）比3例（2．7％），均P〈0．053。结论糖尿病、高血压、BMI增高可单独作为胰腺癌的危险因素，也可能几种因素共同作用影响胰腺癌的发生。

Objective To investigate the correlation of blood glucose, blood pressure and body weight with pancreatic cancer. Methods From January 2011 to December 2013, 110 patients diagnosed with pancreatic cancer in our hospital were selected as the observation group and 110 agematched cases without cancer during the same period were selected as the control group. The percentages of patients with diabetes, hypertension and elevated body mass index （BMI） were analyzed in both groups. Results The number of patients with diabetes was higher in the observation group than in the control group （32 cases or 29.1% w 16 cases or 14.6%, P〈0.05）. The proportions of pancreatic cancer patients with diabetes duration ≤2 years, 2--5 years and 5--10 years were higher in the observation group than in the control group （P〈0.05）. The proportion of subjects with increased BMI was higher in the observation group than in the control group （24.6 % or 27cases w 10.9% or 12 cases, P〈0.05）. The proportions of patients with diabetes combined with increased BMI and of patients with hypertension and increased BMI were higher in the observation group than in the control group （17.3% or 19 cases vs 2.7% or 3 cases, 10.9% or 12 cases vs 2.7% or 3 cases, respectively, P〈0.05 for both）. Conclusions Diabetes, hypertension, and elevated BMI can be considered as risk factors for pancreatic cancer, and it is possible that these factors are involved in the development of pancreatic cancer.