摘要
目的探讨老年急性冠脉综合征(ACS)患者血清胱抑素C(CysC)和同型半胱氨酸(Hcy)水平与Gensini评分的相关性。方法入组患者91例,其中非冠心病对照组20例,稳定性心绞痛(SAP)组28例,ACS组43例,检测3组患者外周血血清中CysC和Hcy水平,同时计算各组患者冠脉病变Gensini评分。结果 ACS患者CysC、Hcy水平与对照组比较均显著升高(P<0.05),ACS组与SAP组组间比较,CysC和Hcy水平有升高趋势,但差异无统计学意义(P>0.05);相关性分析显示CysC与Hcy呈正相关(r=0.284,P<0.05),血清CysC与Gensini评分呈正相关(r=0.321,P<0.005)。结论 ACS患者血清CysC与Hcy水平升高,而血清CysC和Hcy水平与Gensini评分均呈正相关,说明血清CysC与Hcy在一定程度上可以反映冠状动脉病变程度。
Objective To investigate the levels and relationships between the Gensini score and plasma cystatin（ Cys） C,homocycteine（ Hcy） in elderly patients with coronary heart disease（ CHD）. Methods 91 cases were selected： 20 patients excluded the diagnosis of coronary artery disease as control group,28 patients with stable angina pectoris（ SAP）,43 patients with acute coronary syndrome（ ACS）. The levels of Cys C and Hcy of 3 groups were detected. And the patients in SAP and ACS groups were given a mark with Gensini score. Results The levels of blood Cys C and Hcy in ACS group were obviously higher than those in control group（ P〈0. 05）. The levels of Cys C and Hcy were positively correlated（ r = 0. 284,P〈0. 05）. And the level of Cys C was positively related with Gensini score（ r = 0. 321,P〈0. 05）. Conclusions The levels of blood Cys C and Hcy,and the levels of blood Cys C and Gensini score in ACS group are both correlated. These could reflect the level of coronary atherosclerosis to a certain degree.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2016年第4期813-815,共3页
Chinese Journal of Gerontology
基金
国家自然科学基金项目(81202830
81270181)
