喜炎平联合蒙脱石散治疗小儿腹泻疗效及安全性的Meta分析

Meta-analysis on Clinical Efficacy and Safety of Xiyanping Combined with Montmorillonite Power in Treatment of Infantile Diarrhea

目的:评价喜炎平联合蒙脱石散治疗小儿腹泻的疗效及安全性。方法:计算机检索Pubmed,Embase,Cochrane library,中国生物医学文摘数据库(CBM),中国期刊全文数据库(CNKI),维普数据库(VIP)和万方数据库中,关于喜炎平联合蒙脱石散治疗小儿腹泻的随机对照试验(randomized clinical trials,RCT),纳入研究的质量评价和资料提取由两名研究者独立严格进行,采用Rev Man 5.3软件进行Meta分析。结果:最终纳入17个RCT,共1 841例患儿。Meta分析结果显示:喜炎平联合蒙脱石散治疗小儿腹泻在总有效率、止泻时间、大便性状恢复时间等方面与对照组均有统计学意义(P<0.05),在体温下降时间方面,两组比较没有统计学意义。结论:喜炎平联合蒙脱石散治疗小儿腹泻具有一定的疗效性且安全性较高。但现有研究质量偏低,需要更多设计严谨的高质量、多中心的随机双盲临床研究进一步验证。

Objective： To evaluate the efficacy and safety of Xiyanping combined with montmorillonite power in the treatment of infantile diarrhea. Method： literature were retrieved from Pubmed,Embase,Cochrane library,CNKI,CBM,Wanfang Data and VIP to select randomized clinical trials on Xiyanping combined with montmorillonite power for the treatment of infantile diarrhea. Rigorous quality evaluation and data extraction were done independently by two researchers,and treatment,Rev Man 5. 3 software was used for Meta-analysis. Result：17 RCTs were eventually included,with a total of 1 841 cases of children. Meta-analysis showed that： Xiyanping combined with montmorillonite power in the treatment of infantile diarrhea was statistically significant when compared with the control group intotal efficiency,the time of diarrhoea stop and recovery time of abnormal stool（ P〈0. 05）,but there was no statistically significant difference in time of body fever relieving between the two groups. Conclusion： Xiyanping combined with montmorillonite power has a certain effect and high safety in the treatment of infantile diarrhea,but with the poor quality of the existing studies,we need to design more rigorous and high quality multicenter,randomizeed,double-blinded experiments for verification.