不同剂量维生素D对Roux-en-Y胃旁路减重术后骨代谢异常的影响

Different doses vitamin D to bone metabolism in obese persons after Roux-en-Y gastric bypass

目的分析不同剂量维生素D补充对于Roux-en-Y胃旁路术(RYGB)术后6个月患者骨密度的影响。方法将36例RYGB术后患者随机分为对照组(13例)、低剂量组(11例)和高剂量组(12例),观察不同剂量维生素D(400 IU/d和1 600 IU/d)对患者术后6个月骨密度的影响并与对照组比较。结果术后6个月,入选研究对象体质量和身体质量指数(BMI)在术后6个月均明显下降,差异有统计学意义(P<0.05),其中1 600 IU/d的维生素D补充治疗可升高术后患者的血钙和25-羟基-维生素D(25-hydroxyvitamin D,25[OH]D),同时骨密度明显增加,差异有统计学意义(P<0.05)。结论 1 600 IU/d的维生素D补充治疗对于PYGB术后的骨密度降低具有改善作用。

Objective To determine the effect of different doses vitamin D supplementation to the change of bone metabolism in 6months after Roux-en-Y gastric bypass（ RYGB）. Methods The change of body weight and body mass index（ BMI） in 36 patients in 6months after RYGB WAS analyzed. Then,the effect of low-dose（ n = 11,400 IU / day） and high-dose（ n = 12,1 600 IU / day） vitamin D to the serum calcium,25-hydroxyvitamin D and bone density were observed,and 15 patients as control. Results In 6 months after RYGB,the body weight and BMI were decreased,and the differences were statistical significance（ P 〈 0. 05）. The serum calcium,25-hydroxyvitamin D and bone density were increased in high-dose group,and the differences were statistical significance（ P 〈 0. 05）. Conclusion High-dose（ 1 600 IU/day） vitamin D supplementation is effective to the bone loss of patients undergoing RYGB.