乌司他丁对烧伤患者凝血功能及全身炎症反应的影响

The impact of ulinastatinon coagulation function and systemic inflammatory reaction on patients with burn injury

目的明确乌司他丁治疗对烧伤患者凝血功能及全身炎症反应的影响。方法分析2010年1月至2015年1月在我院接受治疗的烧伤患者的临床资料。本研究共纳入烧伤患者78例,依据治疗方法不同将患者分为观察组(使用乌司他丁治疗)及对照组(未使用乌司他丁治疗)。其中观察组患者38例,对照组40例。比较两组患者治疗前后外周血炎症指标及凝血功能指标的改变,及其治疗前后CRP、IL-6、IL-10、PT、APTT、DD、FIB、TT、IgA、IgG、IgM、CD4/CD8等炎症因子、凝血功能及免疫反应指标的变化情况。结果治疗后观察组外周血TNF-α及CRP水平显著低于对照组,差异均具有统计学意义(P<0.05)。治疗后观察组CD4/CD8显著高于入院时(P<0.05),同时显著高于对照组治疗后(P<0.05)。治疗后观察组PT、TT、APTT、D-D及FIB均较入院时显著降低(P<0.05),且显著低于对照组(P<0.05)。结论乌司他丁可有效减轻烧伤患者全身性炎症反应、改善免疫及凝血功能。

Objective Our study was aimed to analyze the impact of ulinastatin on coagulation function and system- ic inflammatory reaction on patients with burn injury. Methods Clinical data of patients with burn injury received treat- ment at our hospital from 2010 to 2015 was analyzed. Patients were divided into Group A （38 cases） with ulinastatin and Group B （40 cases） without ulinastatin. Results After treatment, Group A had lower levels of CRP and TNF-α than these of Group B, but had a higher of CD4/CD8 than that of Group B. The difference was statistically significant （P〈0.05）. After treatment, Group A patients had lower levels of PT,TT, APTT,D-Dand FIB than these before treatment and these of Group B. The difference was statistically significant （P〈0.05）. Conclusion Ulinastatin can be used in treatment of burn with the effects of inhibiting the inflammatory response and protecting the blood coagulation.