新疆地区不同民族人群心房颤动与血清尿酸水平的相关性研究

Relationship between serum uric acid and atrial fibrillation in Uyghur and Han population of Xinjiang

目的 探讨新疆地区维吾尔族、汉族心房颤动（AF）患者心房颤动的发生与血清尿酸水平的关系。方法 以维吾尔族、汉族心房颤动患者各100例作为病例组,以维吾尔族、汉族非心房颤动患者各100例作为对照组,记录各组患者的年龄、性别、尿酸水平,用药情况等。采用Logistic回归分析心房颤动发生的危险因素。结果 维吾尔族、汉族病例组与对照组比较,年龄、低密度脂蛋白、总胆固醇、尿酸水平差异有统计学意义（P〈0.05）,心房颤动组年龄、低密度脂蛋白、总胆固醇和尿酸均显著高于非心房颤动组。多因素Logistic回归分析结果发现,年龄（OR=1.114,95%CI=1.080-1.149,P〈0.01）、总胆固醇（OR=1.902,95%CI=1.434-2.522,P〈0.01）和尿酸（OR=1.023,95%CI=1.017-1.029,P〈0.01）是心房颤动的独立危险因素。结论 在新疆地区维吾尔族和汉族人群中,血清尿酸可能是心房颤动的危险因素。

Objective To explore the relationship between serum uric acid and atrial fibrillation in Uyghur and Han population of Xinjiang. Methods One hundred Uyghur and 100 Han patients with atrial fibrillation were selected as case group, and 100 Uyghur and 100 Han subjects without atrial fibrillation were collected as control group. The baseline of clinical data were collected, including age, gender, risk factors of cardiology diseases, drugs and serum uric acid level. Risk factors of AF were analyzed by Logistic regression analysis. Results The age, low-density lipoprotein, total cholesterol and uric acid of patients with AF were significantly higher than those of control （ P 〈 0.05 ）. Logistic regression analysis showed that the age （ OR = 1.114,95% CI = 1. 080 - 1. 149, P 〈 0. 01 ）, total cholesterol （ OR = 1. 902, 95 % CI = 1. 434 - 2.522, P 〈 0.01 ）, serum uric acid （ OR = 1. 023,95 % CI = 1. 017 - 1. 029, P 〈 0.01 ）were risk factors for the occurrence of AF. Conclusion The serum uric acid is a risk factor of atrial fibrillation in Uyghur and Han population of Xinjiang.