血清γ-谷氨酰转移酶水平与动脉硬化的相关性分析被引量：1

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摘要目的研究血清γ-谷氨酰转移酶(GGT)水平与动脉硬化的相关性。方法选取动脉硬化病例124例,并于同期体检人群选取非动脉硬化病例75例,提取其体格检查、生化检测、动脉硬化检查等指标。通过对其进行分析以明确GGT水平与动脉硬化的相关性。结果动脉硬化组血清GGT水平明显高于对照组(P<0.05),其中中、重度动脉硬化组血清GGT水平又高于对照组(P<0.05)。Logistic回归分析显示:年龄、高血压、高血脂和血清GGT水平是动脉硬化的独立预测因素(相应B、P值分别为-0.669、0.002,1.716、0.002,0.966、0.006,0.622、0.000)。结论动脉硬化患者血清GGT水平高于正常人群,GGT对动脉硬化有预测作用,应该引起重视。

作者白玉杰唐世琪夏洪淼蒋雨玲吴凌云

机构地区武汉大学人民医院体检中心

出处《中国临床保健杂志》 CAS 2016年第1期86-88,共3页 Chinese Journal of Clinical Healthcare

关键词动脉硬化 Γ-谷氨酰转移酶危险因素

分类号 R543.5 [医药卫生—心血管疾病]

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1Whitfield JB. Gamma glutamyl transferase [ J ]. Crit Rev Clin Lab Sei,2001, 38(4) :263-355.
2Nakanishi N, Suzuki K, Tatara K . Serum gamma-glu- tamyltransferase and risk of metabolic syndrome and type 2 diabetes in middle-aged Japanese men [ J ]. Diabetes Care,2004, 27(6): 1427-1432.
3Lee DS, Evans JC, Robins SJ, et al. Gamma glutamyl transferase and metabolic syndrome, cardiovascular dis- ease, and mortality risk-The Framingham Heart Study[ J]. Arterioscler Thromb Vasc Biol,2007, 27 ( 1 ) : 127- 133.
4Ryu S, Chang Y, Woo HY, et al. Longitudinal increase in gamma - glutamyltransferase within the reference inter- val predicts metabolic syndrome in middle - aged Korean men[ J]. Metabolism - Clinical and Experimental ,2010, 59(5) :683-689.
5Ruttmann E, Brant LJ, Concin H, et al. Gamma - glu- tamyhransferase as a risk factor for cardiovascular disease mortality - An epidemiological investigation in a cohort of 163,944 Austrian adults [ J ]. Circulation, 2005, 112 (14) :2130-2137.
6Lee DH, Silventoinen K, Hu G, et al. Serum gamma - glu- tamyhransferase predicts non-fatal myocardial infarction and fatal coronary heart disease among 28,838 middle- aged men and women[J]. Eur Heart J,2006,27 (18) : 2170-2176.
7Boutouyrie P, Tropeano AI, Asmar R, et al. Aortic stiff- ness is an independent predictor of primary coronary e- vents in hypertensive patients : a longitudinal study [ J ]. Hypertension, 2002,39 ( 1 ) : 10 -15.
8Laurent S, Boutouyrie P, Asmar R, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascu- lar mortality in hypertensive patients [ J ]. Hypertension, 2001,37 (5) : 1236-1241.
9Kelly R , Hayward C , Avolio A, et al. Noninvasive de- termination of age-related changes in the human arterial pulse[J]. Circulation,1989,80(6) :1652-1659.
10Kengne AP, Czerniehow S, Stamatakis E, et al. Gamma- gutamyltransferase and risk of cardiovascular disease mor- tality in people with and without diabetes :Pooling of three British Health Surveys [ J ]. J Hepatol , 2012,57 ( 5 ) : 1083-1089.