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KaiB调控蓝藻生物钟振荡的分子机制

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摘要 蓝藻PCC7942的基因簇Kai ABC编码的Kai A、Kai B及Kai C蛋白对单细胞蓝藻的生物节律非常重要。蓝藻翻译后生物钟是受一系列生物化学反应控制的,其中包括磷酸化反应、ATP水解、单体的交换以及各种分子构象的变化,从而维持了生物振荡的准确与精密。本文对近些年来Kai B在翻译后振荡体系中参与Kai蛋白的相互作用而共同调节生物振荡,对ATP酶的影响及诱导Kai C单体的交换等一系列过程进行了综述,并介绍了Kai B与信号输出蛋白Sas A的竞争关系,这对揭示体外生物钟的工作机制有着非常重要的意义。
作者 杨丽婷(综述) 刘森(审校)
机构地区 肿瘤微环境与免疫治疗湖北省重点实验室
出处 《东南国防医药》 2016年第1期68-72,共5页 Military Medical Journal of Southeast China
基金 国家自然科学基金资助项目(21103098)
关键词 KaiB蛋白 磷酸化循环反应 单体的交换 ATP酶活性 SASA
分类号 Q6 [生物学—生物物理学] Q7 [生物学—分子生物学]
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参考文献29

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二级参考文献62

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东南国防医药
2016年 第1期

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