吸烟者血浆可溶性蛋白C受体测定的临床意义及影响因素分析

Clinical Significance of the Plasma Soluble Endothelial Protein C Receptor Measurement and the Relative Influencing Factors in Cigarettes Smoking

目的测定吸烟者血浆可溶性蛋白C受体(s EPCR)水平,探讨其临床意义及影响s EPCR的相关因素。方法测定643例健康人员血浆s EPCR和蛋白C(PC)浓度和凝血因子Ⅷ和Ⅴ(FⅧ:C和FⅤ:C)以及D-二聚体(D-D)水平,并调查其年龄、吸烟和戒烟、吸烟剂量等情况,分为吸烟组和不吸烟组。结果吸烟组s EPCR、FⅧ:C、FⅤ:C和D-D水平均显著高于不吸烟组(P均=0.000)。吸烟组s EPCR浓度与FⅧ:C、FⅤ:C和D-D水平均呈较高程度正相关(P<0.01)。在吸烟与不吸烟组、不同吸烟年限组以及不同吸烟剂量组中,s EPCR浓度均随年龄段增大而增加(P均<0.01)。不同年龄段中,吸烟组和高剂量组s EPCR浓度分别显著高于不吸烟组和低剂量组(P均<0.05)。在不同年龄段组和不同性别组中,s EPCR浓度均随吸烟年限增加而增高(P均<0.05);不同年限吸烟者中,男性组与女性组之间s EPCR浓度差异均无统计学意义(P>0.05)。结论吸烟者血栓风险增高可能与血浆s EPCR水平升高有关,烟龄、年龄和吸烟剂量是影响吸烟者血浆s EPCR水平的重要因素。

Objective To measure the levels of plasma soluble endothelial proteinC receptor （sEPCR） in cigarettes smoking, and to explore its clinical significance and the influencing factors of cigarettes smoking on sEPCR. Methods Plasma sEPCR,coagulating factor Ⅷ , V procoagulant activities （FⅧ ：C, FV ：C） and D - dimer （D - D） level were measured in 643 healthy participants. The status of age, cigarettes smoking and smoking quiting, and smoking dose were conveyed. Then all participants were assigned two groups： group cigarettes somking and group non - cigarettes somking. Results Levels of sEPCR, FⅧ ：C, F V ：C, and D - D in group cigarettes somking were significantly higher than that in group non -cigarettes somking （P = 0. 000）. The sEPCR level was more closely related to that of F VⅧ：C, F V ：C and D- D（P 〈 0.01 ）. In both group cigarettes somking and noncigarettes somking, groups of different smoking durations, and groups of different smoking dose, sEPCR levels were remarkably elevated with increased age intervals （P 〈 0.01 ）. For all somkers of different age intervals, sEPCR levels in group of cigarettes somking and group of high dose smoking were significantly higher than those in group of non - cigarettes somking and group of low dose smoking, respectively （ P 〈 0.05 ）. In groups of different age intervals, and groups of male and female, sEPCR levels were elevated with increased smoking durations （P 〈 0.05）. In different smoking durations, there was no stastistical difference is sEPCR levels between male and female （P 〉 0. 05 ）. Conclusion High risk of thrombosis in cigarettes smokersis probabbly related to elevated plasma sEPCR levels, and smoking duration, age and smoking dose are the important factors to influence sEPCR levels.