摘要
胰腺癌是高度恶化的恶性肿瘤,预后极差。慢性胰腺炎是导致胰腺癌的独立危险因素,吸烟、肥胖、胰腺癌家族史等是慢性胰腺炎癌变的危险因素。慢性胰腺炎恶性转化过程中的信号调控通路一直是国内外学者研究的热点。本文就慢性胰腺炎转化为胰腺癌的过程中通路相关的病变机制研究进展进行综述。
Pancreatic cancer is one of the most lethal and intractable human malignancies with poor prognosis. Chronic pancreatitis is the independent risk factor for pancreatic cancer. Smoking, obesity and family history are the risk factors for chronic inflammation-associated pancreatic carcinogenesis. Recent studies of signal pathways have made a significant progress in our understanding of chronic pancreatitis in pancreatic cancer. This review summarizes recent development in the important signal pathways involved in pancreatic carcinogenesis from chronic pancreatitis.
出处
《药学学报》
CAS
CSCD
北大核心
2016年第2期174-181,共8页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(91229114)
关键词
慢性胰腺炎
癌变
发病原因
发病关键信号通路
非编码RNA
chronic pancreatitis
pancreatic carcinogenesis
etiopathogenesis
important pathogenesis related signal pathway
non-coding RNA
