脂联素与肺癌合并COPD患者肺功能、年龄、性别的相关性分析

Analysis of the Correlation between Adiponectin and Pulmonary Function,Age and Gender of Lung Cancer Patients with COPD

目的探讨脂联素和肺癌合并COPD患者肺功能、年龄、性别的相关性。方法选取肺癌合并COPD患者90例,分为重症组和稳定组。45例健康者作为健康组。测量3组研究对象的肺功能指标(FEV1/FVC以及FEV1%)以及血清中脂联素的含量,并确定脂联素与COPD患者肺功能、年龄、性别的相关性。结果 3组被研究对象组内性别间的脂联素含量的差异均具有统计学意义(P<0.05),女性高于男性,且组间的男性和女性脂联素含量的差异具有统计学意义(P<0.05);FEV1/FVC比值比较,3组被研究对象间男性和女性的差异具有统计学意义(P<0.05);FEV%预计值比较,3组被研究对象间男性和女性的差异具有统计学意义(P<0.05)。COPD患者的血清中脂联素水平与FEV1/FVC(γ男=-0.642,γ女=-0.657)和FEV%预计值(γ男=-0.819,γ女=-0.751)均呈负相关性。在3组被研究对象中,只有健康组患者男性中脂联素含量水平与年龄呈正相关性,其他的均无明显的相关性。结论肺癌合并COPD患者中血清脂联素与肺功能和性别存在明显的关系,而与患者的年龄分布的关系不明显。

Objective To investigate the correlation between adiponectin and pulmonary function,age and gender of lung cancer patients with COPD. Methods 90 cases of COPD patients,were divided into the severe group and the stable group. 45 healthy patients as the healthy group. The indexes of lung function of the 3 groups（ FEV1 / FVC and FEV1%） and the content of serum adiponectin should be measured,and determine the relationship between adiponectin and pulmonary function,age and gender of lung cancer patients with COPD. Results The difference of adiponectin content in the 3 group were statistically significant（ P〈 0. 05）,female patients was higher than in male patients,there were significant differences between the 2 groups in adiponectin content（ P〈 0. 05）; compared with the ratio of FEV1 / FVC,there were significant differences between male and female subjects in the 3 groups（ P〈 0. 05）,compared with FEV% expected value,there were significant differences between male and female subjects in the 3 groups（ P〈 0. 05）,and the levels of adiponectin and FEV1 / FVC in the serum of COPD patients（ γmale=- 0. 642,γfemale=- 0. 657 FEV% and FEV% expected value of male（ γmales=- 0. 819,γfemale=- 0. 751） showed a negative correlation; in the 3 groups,adiponectin level of healthy male patients had positive correlation with age,the other has no obvious correlation. Conclusion There has obvious relationship in serum adiponectin,pulmonary function and sex of COPD patients,and has no obvious relations with age distribution.