乳头状肾细胞癌临床病理分析并文献复习

Clinical Pathological Analysis and Literature Review of Papillary Renal Cell Carcinoma

目的探讨乳头状肾细胞癌的临床病理特征、诊断及鉴别诊断、治疗方法和预后。方法对9例乳头状肾细胞癌的临床病理和免疫组织化学特点进行分析对比,并结合相关文献复习。结果 9例肾乳头状肾细胞癌组织学形态相似,癌瘤无包膜,呈浸润性生长,癌细胞胞质嗜酸性和(或)嗜碱性,并呈乳头状、乳头小梁状或乳头实体状排列,乳头有纤维血管轴心,轴心内易见泡沫细胞。免疫组化结果显示,癌细胞CK、EMA、CD10、Vimentin普遍呈阳性。结论乳头状肾细胞癌在肾上皮性肿瘤中相对少见,发生率不足15%,根据其典型的组织学形态并结合免疫组织化学染色有助于诊断及鉴别诊断。

Objective To investigate and discuss the clinical pathological features,diagnosis and differential diagnosis,treatment and prognosis of papillary renal cell carcinoma. Methods Clinical pathological and immunohistochemical features of 9cases of papillary renal cell carcinoma were compared,and the review of the literatures were analyzed. Results 9 cases of papillary renal cell carcinoma had similar histology shape,these tumors had no envelope,and infiltrating growth. The tumor cells had eosinophilic or basophilous cytoplasm,and had papillary,papillary-bridge or papillary-solid architecture. Foam cells were seen in some papillary cores and stroma. Immunohistochemically,the tumor cells universally showed positive immunostaining for CK,EMA,CD10,Vimentin. Conclusion Papillary renal cell carcinoma is relatively rare in renal epithelial tumors,whose incidence is less than 15%,their typical histology shape and immunohistochemistry staining are helpful for diagnosis and differential diagnosis.