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高尿酸血症对慢性肾脏病的作用及机制研究 被引量:12

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摘要 临床高尿酸血症(HUA)逐渐增多,以往认为其仅为慢性肾脏病(CKD)患者慢性肾功能不全的标志之一,近年来研究发现HUA主动参与了CKD的发生发展。作用机制包括氧化应激、炎症反应、肾素-血管紧张素系统(RAS)激活、一氧化氮合酶(NOS)抑制和上皮间质转分化(EMT)等所致肾血管病变和肾小管间质损伤。
作者 董杨 程丽静
出处 《微循环学杂志》 2016年第1期72-74,共3页 Chinese Journal of Microcirculation
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