摘要
目的 探讨进展期胃癌（AGC）血清CD4＋T细胞、CD8＋T细胞亚群检测的临床价值.方法 采用流式细胞术检测20例AGC患者（AGC患者组）和20例健康成人（健康对照组）血清CD4＋T细胞、CD8＋T细胞亚群水平并比较其差异;检测AGC患者组患者手术治疗前后血清CD4＋T细胞、CD8＋T细胞亚群水平并比较其差异.结果 AGC患者组较健康对照组受试者血清CD4＋T细胞水平降低而CD8＋T细胞水平升高,AGC患者组手术治疗后CD4＋T细胞水平升高而CD8＋T细胞水平降低,差异有统计学意义（P＜0.01）.结论 血清CD4＋T细胞、CD8＋T细胞亚群检测有助于评估AGC患者机体的免疫状态,对AGC的病情监测具有一定的临床价值.
Objective To explore the clinical value of combined detection of serum CD4 ＋ T cells and CD8 ＋ T cells for advanced gastric cancer （AGC）.Methods Serum levels of CI4 ＋ T cells and CD8 ＋ T cells were measured by flow cytometry and compared in 20 patients with AGC （experimental group） and 20 healthy adults （control group）.Also,serum levels of CD4 ＋ T cells and CD8 ＋ T cells were measured by flow cytometry and compared before and after surgical treatment in the patients of experimental group.Results The serum levels of CD4 ＋ T cells were decreased and CD8 ＋ T cells were increased in patients with AGC.However,the serum levels of CD4 ＋T cells were increased and CD8 ＋T cells were decreased after surgical treatment （P 〈 0.05）.Conclusions The serum levels of CD4 ＋ T cells and CD8 ＋ T cell help to assess the immune status of patients with AGC,which contributes to the illness monitoring for AGC.
出处
《中国医师杂志》
CAS
2016年第1期60-62,共3页
Journal of Chinese Physician
基金
四川省卫生厅科学研究项目（090250）
