摘要
目的 探讨进展期胃癌(AGC)血清CD4+T细胞、CD8+T细胞亚群检测的临床价值.方法 采用流式细胞术检测20例AGC患者(AGC患者组)和20例健康成人(健康对照组)血清CD4+T细胞、CD8+T细胞亚群水平并比较其差异;检测AGC患者组患者手术治疗前后血清CD4+T细胞、CD8+T细胞亚群水平并比较其差异.结果 AGC患者组较健康对照组受试者血清CD4+T细胞水平降低而CD8+T细胞水平升高,AGC患者组手术治疗后CD4+T细胞水平升高而CD8+T细胞水平降低,差异有统计学意义(P<0.01).结论 血清CD4+T细胞、CD8+T细胞亚群检测有助于评估AGC患者机体的免疫状态,对AGC的病情监测具有一定的临床价值.
Objective To explore the clinical value of combined detection of serum CD4 + T cells and CD8 + T cells for advanced gastric cancer (AGC).Methods Serum levels of CI4 + T cells and CD8 + T cells were measured by flow cytometry and compared in 20 patients with AGC (experimental group) and 20 healthy adults (control group).Also,serum levels of CD4 + T cells and CD8 + T cells were measured by flow cytometry and compared before and after surgical treatment in the patients of experimental group.Results The serum levels of CD4 + T cells were decreased and CD8 + T cells were increased in patients with AGC.However,the serum levels of CD4 +T cells were increased and CD8 +T cells were decreased after surgical treatment (P 〈 0.05).Conclusions The serum levels of CD4 + T cells and CD8 + T cell help to assess the immune status of patients with AGC,which contributes to the illness monitoring for AGC.
出处
《中国医师杂志》
CAS
2016年第1期60-62,共3页
Journal of Chinese Physician
基金
四川省卫生厅科学研究项目(090250)