血清Chemerin水平在宫颈上皮内瘤变及宫颈癌中的表达及临床意义

The expression and clinical significance of Chemerin in cervical intraepithelial neoplasia and cervical cancer

目的 探讨宫颈上皮内瘤变（CIN）及宫颈癌患者血清Chemerin表达水平与宫颈癌临床病理特征的关系.方法 应用酶联免疫吸附试验（ELISA）测定20例CIN及35例宫颈癌患者及20例健康对照患者的血清Chemerin水平,分析其表达水平与临床病理特征的关系.结果 宫颈癌组血清Chemerin水平[（2113.35±198.64） ng/L]显著高于CIN组[（1562.78±158.65） ng/L]和健康对照组[（946.36±113.57）ng/L]（t =30.27,P=0.000;t=75.01,P=0.000）,而CIN组血清Chemerin水平明显高于健康对照组（t=51.48,P=0.000）.宫颈癌患者血清Chemerin水平表达升高与国际妇产科联盟（FIGO）分期及淋巴结转移有关（P＜0.05）.血清Chemenn水平与FIGO分期呈正相关（rs=0.92,P=0.000）.结论 宫颈癌患者外周血Chemerin水平显著升高,与FIGO分期密切相关,与淋巴结转移有关,对于预测宫颈癌进展程度具有一定的指导作用.

Objective To investigate the expression of Chemerin in cervical intraepithelial neoplasia（CIN） and cervical cancer and its relation with clinicopathological characteristics.Methods The expression of Chemerin was determined with enzyme-linked immunosorbent assay （ELISA） in 35 cervical cancer cases,20 cervical intraepithelial neoplasia cases and 20 normal persons.The association of serum level of Chemerin with clinicopathological charactersistics was analyzed.Results The level of Chemerin was the highest in cervical cancer cases [（2113.35 ± 198.64） ng/L],higher in CIN [（1562.78 ± 158.65） ng/L],and low in normal persons [（946.36 ± 113.57） ng/L],showing significant difference among three groups.The serum level of Chemerin in cervical cancer were positively correlated with Federation International of Gynecology and Obstetrics （FIGO） stage and lymph node metastasis （P 〈 0.05）.Serum Chemerin levels were increased with clinical FIGO stage and showed significantly positive correlation with FIGO stage （rs =0.92,P =O.000）.Conclusions The expression of Chemerin in patients with cervical carcinoma is increased.Chemerin may be used as reference indicator to predict its progression in cervical carcinoma.