摘要
目的了解健康人群A和C群流行性脑脊髓膜炎(简称流脑)抗体水平,为制定预防控制措施提供依据。方法 2014年对天津市河北区和武清区健康人群进行了分层随机抽样调查,采集静脉血482份,用酶联免疫吸附试验方法检测A和C群流脑IgG抗体水平。结果 A群流脑抗体阳性率为64.32%,抗体平均浓度为8.63μg/ml;C群流脑抗体阳性率为52.90%,抗体平均浓度为4.78μg/ml。0~1岁组A群流脑抗体阳性率和抗体平均浓度均最低,分别为51.67%和5.70μg/ml;C群流脑抗体阳性率及抗体平均浓度均以15~19岁组最低,分别为38.33%和2.86μg/ml,5~6岁组最高,分别为72.13%和7.73μg/ml。各年龄组A和C群流脑抗体阳性率及抗体平均浓度差异均有统计学意义(P〈0.05)。不同接种剂次人群的抗体阳性率和平均浓度差异均有统计学意义(P〈0.05)。结论这两个地区健康人群流脑抗体水平较低,应引起注意,加强疫苗接种工作。
[Objective]To understand the antibody level against group A and C epidemic cerebrospinal meningitis(ECM)in healthy population,provide evidence for formulating prevention and control measures. [Methods]By the stratified random sampling method,482 healthy subjects were selected from Hebei District and Wuqing District in Tianjin in 2014,to collect the venous blood samples. The levels of antibody against group A and C ECM were tested by ELISA. [Results]The positive rate of antibody against group A ECM was 64.32% and the mean antibody concentration was 8.63 μg/ml,while the positive rate of antibody against group C ECM was 52.90% and the mean antibody concentration was 4.78 μg/ml. The positive rate and mean concentration of antibody against group A ECM in 0-1 year-old age group was the lowest,which was 51.67% and 5.70 μg/ml respectively. The positive rate and mean concentration of antibody against group C ECM in 15-19 year-old age group was the lowest,which was38.33% and 2.86 μg/ml respectively,and those in 5-6 year-old age group was the highest,which was 72.13% and 7.73 μg/ml respectively. There were significant differences in positive rate and mean concentration of antibody against group A and C ECM among different age group(P 〈0.05). The differences in positive rate and mean concentration of antibody against ECM were significant among different doses of vaccine(P〈0.05).[Conclusion]The levels of antibody against ECM are low relatively among healthy population in two districts. It is necessary to pay attention to this problem,and strengthen effective vaccination.
出处
《职业与健康》
CAS
2016年第2期259-261,264,共4页
Occupation and Health
关键词
流行性脑脊髓膜炎
健康人群
抗体
Epidemic cerebrospinal meningitis(ECM)
Healthy population
Antibody