右美托咪定在乳腺癌手术麻醉中的应用效果

Application of dexmedetomidine in the anesthetic management of breast cancer surgery

目的探讨右美托咪定(Dex)在乳腺癌手术静脉吸入复合麻醉(VICA)中的应用效果。方法选取70例确诊为乳腺癌的患者,按随机数字表法将其随机分成Dex组和对照组,各35例。2组患者均在VICA条件下行乳腺癌手术,Dex组患者在术中辅以静脉泵注Dex治疗,对照组患者辅以静脉泵注0.9%氯化钠注射剂,之后比较2组患者的麻醉效果。结果 Dex组患者术中的平均动脉压、心率均较对照组有所改善,术中不良事件的发生率以及OAA/S和躁动评分均较对照组低,差异均具有统计学意义(P<0.05)。结论在乳腺癌手术VICA中辅以Dex治疗的麻醉效果较好,具有较高的临床应用价值。

AIM To investigate the effects of dexmedetomidine vein inhalation combined anesthesia （VICA） in breast cancer operation. METHODS A total of 70 breast cancer patients were randomly divided into dexmedetomidine group （35 patients） and control group （35 patients） according to random number table. The above 2 groups of patients received breast cancer surgery under VICA with dexmedetomidine or 0.9% sodium chloride injection as adjuvant drug, respectively~ The effects of anesthesia were compared . RESULTS The mean arterial pressure and heart rate in dexmedetomidine group were significantly better than those of control group with low incidence of adverse events. OAA/ S scale and sedation-agitation scale in dexmedetomidine group were both improved （P 〈 0.05 ）. CONCLUSION Dexmedetomidine should be selected as adjuvant drug in the anesthesia of breast cancer surgery for the ideal aid in anes- thesia, which has higher clinical application value.