摘要
目的:通过Meta分析进一步探究IL-1β基因3954C〉T位点多态性改变与侵袭性牙周炎的相关性。方法:检索PubMed,Embase,CNKI和万方数据库中有关IL-1β基因3954C〉T位点多态性与侵袭性牙周炎易感性相关文献,以OR值和95%的可信区间为效应指标,应用STATA11.0软件进行Meta分析,并对发表偏倚及敏感性分析进行检验。结果:纳入22个病例对照研究,共计965例侵袭性牙周炎患者和1234例对照,Meta分析结果显示,总人群中,IL-1β基因3954C〉T位点多态性与牙周病风险之间没有显着关联(T vs.C:OR=0.966,95%CI=0.696-1.341;CTVS.CC:OR=0.936,95%CI=0.761~1.151:TT VS.CC:OR=0.892,95%CI=0.464-1.715:CT+TFVS.CC:OR=1.026,95%CI=0.795—1.323;TrVS.CC+CT:OR=0.864,95%CI=0.436、1.713)。相应的亚组分析未发现IL-1β基因3954C〉T位点多态性和侵袭性牙周炎易感性无显著相关性。结论:IL-1β基因3954C〉T位点多态性多态性可能与侵袭性牙周炎的发生无关。
Objective:To investigate the association between IL-l[33954C〉T polymorphism and aggressive pedodontitis (AgP) susceptibility through recta-analysis. Method:Electronic databases were searched from Pub Med,Embase databases. Odds ratio (OR) with 95 % confidence interval (CI) and publish bias was applied with STATA 11.0 software. Result: Twenty-two included case-control studies including 965 patients with AgP and 1234 controls were selected. Overall, no significant association between IL-1133954C〉T polymorphism and AgP risk was found in this recta-analysis (T vs. C: 0R=0.966, 95 % CI=0.696-1.341 ; CT vs. CC: OR=0.936, 95 % CI=0.761-1.151 ; TT vs. CC: 0R=0.892, 95 % CI-0.464- 1.715;CT+TT vs. CC:OR=1.026,95 % CI=0.795-1.323;TT vs. CC+CT:OR=0.864,95 % CI=0.436-l.713). In the subgroup analysis, no significant association was detected in the other genetic models. Conclusion: This meta-analysis demonstrates that IL-1β33954C〉T polymorphism may be not a risk factor for AgP development.
出处
《临床口腔医学杂志》
2016年第1期6-9,共4页
Journal of Clinical Stomatology
基金
湖北省教育厅重点项目(D20142102)