IL-1β基因3954C>T位点多态性与侵袭性牙周病易感性的Meta分析

Association between IL-1β3954C>T polymorphism and aggressive periodontitis susceptibility:a meta-analysis

目的：通过Meta分析进一步探究IL-1β基因3954C〉T位点多态性改变与侵袭性牙周炎的相关性。方法：检索PubMed，Embase，CNKI和万方数据库中有关IL-1β基因3954C〉T位点多态性与侵袭性牙周炎易感性相关文献，以OR值和95％的可信区间为效应指标，应用STATA11．0软件进行Meta分析，并对发表偏倚及敏感性分析进行检验。结果：纳入22个病例对照研究，共计965例侵袭性牙周炎患者和1234例对照，Meta分析结果显示，总人群中，IL-1β基因3954C〉T位点多态性与牙周病风险之间没有显着关联（T vs．C：OR=0．966，95％CI=0．696-1.341；CTVS．CC：OR=0．936，95％CI=0．761～1．151：TT VS．CC：OR=0．892，95％CI=0．464-1．715：CT＋TFVS．CC：OR=1．026，95％CI=0．795—1．323；TrVS．CC＋CT：OR=0．864，95％CI=0．436、1．713）。相应的亚组分析未发现IL-1β基因3954C〉T位点多态性和侵袭性牙周炎易感性无显著相关性。结论：IL-1β基因3954C〉T位点多态性多态性可能与侵袭性牙周炎的发生无关。

Objective：To investigate the association between IL-l[33954C〉T polymorphism and aggressive pedodontitis （AgP） susceptibility through recta-analysis. Method：Electronic databases were searched from Pub Med,Embase databases. Odds ratio （OR） with 95 % confidence interval （CI） and publish bias was applied with STATA 11.0 software. Result： Twenty-two included case-control studies including 965 patients with AgP and 1234 controls were selected. Overall, no significant association between IL-1133954C〉T polymorphism and AgP risk was found in this recta-analysis （T vs. C： 0R=0.966, 95 % CI=0.696-1.341 ; CT vs. CC： OR=0.936, 95 % CI=0.761-1.151 ; TT vs. CC： 0R=0.892, 95 % CI-0.464- 1.715;CT＋TT vs. CC：OR=1.026,95 % CI=0.795-1.323;TT vs. CC＋CT：OR=0.864,95 % CI=0.436-l.713）. In the subgroup analysis, no significant association was detected in the other genetic models. Conclusion： This meta-analysis demonstrates that IL-1β33954C〉T polymorphism may be not a risk factor for AgP development.