柴胡龙骨牡蛎汤联合抗抑郁药物治疗脑卒中后抑郁的肝肾阴虚证的临床研究

Research the effect of Chaihu Longgu Muli decoction with antidepressant therapy in depression after stroke with kidney Yin deficiency syndrome

目的:探讨脑卒中后抑郁证属肝肾阴虚接受联合柴胡龙骨牡蛎汤及抗抑郁药物治疗的治疗效果,为临床治疗提高参考。方法:应用随机数字表法将80例缺卒中后抑郁证属肝肾阴虚患者分为两组,每组40例。以接受常规抗抑郁药物治疗者为对照组,以接受联合柴胡龙骨牡蛎汤及抗抑郁药物治疗者为治疗组,对比两组临床治疗效果。结果:治疗前两组间各项中医症状积分、中医症状总积分、汉密尔顿焦虑评分(HAMD)比较未见统计学差异(P>0.05),而在接受治疗4周后,治疗组各项中医症状积分、中医症状总积分及HAMD均明显低于对照组(P<0.05)。治疗前两组间GQOLI-74各项评分及总评分比较未见统计学差异(P>0.05),而在接受治疗4周后,治疗组GQOLI-74各项评分及总评分均明显高于对照组。结论:在常规抗抑郁治疗的同时,联合应用柴胡龙骨牡蛎汤可有效的改善脑卒中后抑郁证属肝肾阴虚患者的临床治疗效果。

Objective：To research the effect of Chaihu Longgu Muli decoction with antidepressant therapy in depression after stroke with kidney Yin deficiency syndrome.Methods：Application of random number table method,80 cases of poststroke depression belongs to the liver and kidney Yin deficiency patients were divided into two groups,40 cases in each group.Accept conventional antidepressant treatment as control group,accept Chaihu Longgu Muli decoction with antidepressant therapy as observation group.Compared two groups of clinical therapeutic effect.Results：There was no statistical difference of the TCM symptom score Chinese medicine symptom integral and Hamilton anxiety scale（HAMD）between the two groups before treatment（P〉0.05）,But after 4weeks treatment,all the symptoms of TCM,TCM symptoms total integral and HAMD of observation group were significantly lower than control group（P〈0.05）.There was no statistical difference of GQOLI-74 between the two groups before treatment（P〉0.05）,and after 4weeks treatment,the observation group of GQOLI-74 score and total score were significantly higher than the control group.Conclusion：In conventional antidepressant treatment at the same time,the combined use of Chaihu Longgu Muli decoction can effectively improve the depression after stroke clinical outcomes of patients with liver and kidney Yin deficiency.