杞菊地黄汤对老年高血压患者血压变异的影响

Effects of Qiju Dihuang decoction on blood pressure variability in elderly hypertensive patients

目的:观察杞菊地黄汤对老年高血压患者血压变异性以及血浆血管紧张素Ⅱ(AngⅡ)和高敏C反应蛋白(hsCRP)水平的影响。方法:56例原发性高血压老年患者,随机分为对照组和治疗组,对照组给予苯磺酸左旋氨氯地平片5mg/d,治疗组给予苯磺酸左旋氨氯地平片5mg/d加服杞菊地黄汤,连续治疗4周。动态血压监测法记录24h、日间、夜间收缩压、舒张压平均值及标准差(STD)。自动生化分析仪检测血脂水平,酶标多克隆抗体夹心法检测AngⅡ和hs-CRP浓度。结果:两组患者药物治疗后,血压值与治疗前比较均有不同程度的降低,而治疗组的24h收缩压(24hSBP)和日间收缩压(dSBP)在药物治疗后较对照组显著降低(P<0.05)。对照组在治疗前后的血压变异值未见显著变化;而治疗组患者的24hSBPSTD和dSBPSTD,在治疗前后均有显著性差异(P<0.05),两组治疗后的24hSBPSTD和dSBPSTD也存在显著差异(P<0.05)。此外,对照组在治疗前后的AngⅡ、hsCRP和血脂水平未见显著变化;而治疗组患者的AngⅡ、hsCRP、TG和LDL-C水平,均较治疗前显著降低(P<0.05)。结论:杞菊地黄汤可以显著降低老年高血压患者24h收缩压变异性和日间收缩压变异性,并改善血浆AngⅡ、hsCRP和血脂水平。

Objective：To observe the effects of Qiju Dihuang decoction on blood pressure variability and plasma angiotensin II（AngII）and high sensitive C reactive protein（hsCRP）levels in elderly hypertensive patients.Methods：56elderly hypertensive patients were randomly divided into control group and treatment group.The control group was given Levamlodipine Besylate Tablets 5mg/d,and the treatment group was given Levamlodipine Besylate Tablets 5mg/d plus Qiju Dihuang decoction for 4weeks.Ambulatory blood pressure monitoring method was used to record the mean value and standard deviation of systolic pressure and diastolic pressure for 24 h,daytime and nighttime.The serum lipid levels was detected by automatic biochemical analyzer,and AngII and hs-CRP levels were measured by ELISA method.Results：Compared with pre-treatment,the patients in the two groups have a significant decrease in blood pressure,and the 24 h SBP and dSBP in the treatment group was markedly lower than that in the control group（P〈0.05）.In control group,the variability of blood pressure values had no change in before and after treatment.However,24 hSBPSTD and dSBPSTD in treatment group were significant differences in before and after treatment（P〈0.05）,and there was also significant difference in 24 hSBPSTD and dSBPSTD of the two groups after treatment（P〈 0.05）.In addition,the levels of AngII,hsCRP and blood lipid were no change in control group.In the patients of treatment group,AngII,hsCRP,TG and LDL-C levels were significantly lower than those before therapy（P〈0.05）.Conclusion：Qiju Dihuang decoction can significantly reduce the systolic blood pressure variability in 24 hand daytime,and improve plasma levels of AngII,hsCRP and blood lipid in elderly hypertensive patients.