氨磺必利与利培酮对女性精神分裂症患者血清催乳素的影响研究

The influence of serum prolactin between amisulpride and risperidone in female patients

目的比较氨磺必利与利培酮对女性精神分裂症患者的疗效及其对血清催乳素的影响。方法将78例符合《美国精神障碍诊断统计手册》(第5版)精神分裂症诊断标准的患者随机分为氨磺必利治疗组38例和利培酮治疗组40例,观察期为6个月,分别于治疗前及治疗后4周、8周、3个月、6个月进行阳性与阴性症状量表、副反应量表及血清催乳素测定。结果氨磺必利组与利培酮治疗效果差异无显著性(P>0.05),两组治疗前及治疗后4周、8周、3个月、6个月的阳性与阴性症状量表总分及各因子分显著减少(P<0.01)。氨磺必利组与利培酮组在治疗后4周、8周、3个月、6个月血清催乳素水平均明显增加,差异无显著性(P>0.05)。利培酮组出现闭经、泌乳不良反应患者较多,差异有显著性(P<0.05)。结论氨磺必利和利培酮治疗精神分裂症疗效相当,血清催乳素水平也都有明显增加,但氨磺必利组不良反应较轻。

Objective Comparing the therapeutic effect of amisulpride and risperidone in female patients with schizophrenia and its influence on serum prolactin. Method The 78 cases accord with the DSM-5 diagnostic criteria of schizophrenia patients were randomly divided into 38 cases of amisulpride treatment group and 40 cases of risperidone treatment group, observation period for 6 months, respectively before treatment, after treatment of 4 weeks, 8 weeks, 3 months, 6 months for positive and negative symptoms scale, treatment emergent symptom scale and serum prolactin. Result The therapeutic effect of amisulpride and risperidone was no significant difference, the two groups before treatment and after treatment of 4 weeks, 8 weeks, 3 months, 6 months PANSS score and each factor score significantly reduced（P〈0.01）. Amisulpride treatment group and risperidone treatment group after treatment of 4 weeks, 8 weeks, 3 months, 6 months the serum prolactin levels were significantly increased, there was no significant difference. Risperidone treatment group appears amenorrhoea, lactation adverse reactions of patients is more, there are significant difference（P〈0.05）. Conclusion The therapeutic effect of amisulpride and risperidone is equivalence with schizophrene, the level of serum prolactin has increased significantly, but the adverse reactions of amisulpride treatment group is lighter.