乳腺癌的MRI征象与bcl-2、p53表达的相关性研究

Correlative Study of MRI Features and Expression of bcl-2,p53 in Breast Carcinoma

目的探讨乳腺癌的MRI征象与bcl-2、p53表达的相关性。方法对25例乳腺癌和26例乳腺良性肿块的患者术前进行了MRI检查(平扫、DWI及增强),对MRI征象,如病灶的形态、边缘、早期强化、ADC值、强化曲线类型及淋巴结转移进行了分析。术后标本采用免疫组织化学(S-P)法,测定bcl-2、p53表达的情况。然后分析其病变的MRI征象与bcl-2、p53表达的相关性。结果乳腺癌的MRI征象(不规则或毛刺形状、较低ADC值、强化曲线Ⅱ及Ⅲ类型、淋巴结转移)与bcl-2的表达明显负相关(P<0.01),与p53的表达呈正相关(P<0.01)。结论乳腺癌MRI的征象与bcl-2、p53的表达密切相关,可以间接地反映乳腺癌的某些分子生物特性,有助于指导临床治疗及预后的评估。

Objective Objective To investigate the relationship between MRI features and expression of bcl-2, p53 in breast carcinoma. Methods In 25 cases with breast cancer and 26 cases of benign breast tumor patients with preoperative MRI examination（plain scan, DWI and enhanced）, MRI findings of lesions, such as morphology, edge, early intensive, ADC value, enhancement curve type and lymph node metastasis were analyzed.the immunohistochemical（S-P） method was used to test the expression of bcl-2, p53 in postoperative samples, then analyzed the relationship of MRI features and expression of bcl-2, p53 of the lesions. Results Results The MRI features of breast cancer（irregular or burr shape, lower ADC, enhancement curve and type II and III, lymph node metastasis） were significantly negatively correlated with the expression of Bcl-2（P〈0.01）,and significantly positively correlated with the expression of p53（P〈0.01）. Conclusion MRI signs of breast cancer is closely correlated with the expression of bcl-2, p53, may indirectly reflect certain molecular biological characteristics of breast cancer, help to guide the clinical treatment and prognostic evaluation.