miRNA21在溃疡性结肠炎患者中表达的意义

Analyze the Expression of miRNA21 in the Patients with Ulcerative Colitis

目的研究溃疡性结肠炎患者血清mi RNA21的水平,并探讨其在溃疡性结肠炎发展中的意义。方法选取溃疡性结肠炎患者25例及正常对照组20例,采用q RT-PCR方法检测血清mi RNA21的水平。结果溃疡性结肠患者血清mi RNA21的水平为1.32±0.24,正常对照组血清mi RNA21的水平为1.11±0.17。溃疡性结肠组有轻度升高,且差异有统计学意义(P<0.05)。结论溃疡性结肠炎患者血清mi RNA21的表达上调,可能为溃疡性结肠炎的治疗及临床诊断提供新的方向。

Objective Analysis of mi RNA21 in the patients with ulcerative colitis to investigate the pathogenesis of ulcerative colitis. Methods 25 patients with ulcerative colitis and 20 healthy controls were detected. And the expression of mi RNA21 was evaluated by using quantitative real-time polymerase chain reaction（QRT-PCR） analysis. Results mi RNA21 in serum of patients with ulcerative colitis was 1.32±0.24, higher than that 1.11±0.17 of the healthy control group, the difference had statistical significance（P〈0.05）. Conclusion The up-regulated expression of mi RNA21 in the patients with ulcerative colitis might provide a new direction of therapy and clinical diagnosis for ulcerative colitis.