应用病毒治疗结直肠癌的研究进展

Advances in virus-based therapies for colorectal cancer

基于病毒的抗肿瘤治疗是一种新兴的生物治疗方式,病毒载体感染肿瘤组织,引起溶瘤效应,制成疫苗激活体内抗肿瘤免疫,搭载基因行癌症的基因治疗。随着对病毒的不断改造,各类病毒治疗肿瘤更趋于安全和高效,同时,病毒载体与现有的抗肿瘤疗法合理联用,可提高治疗效果。因此,基于病毒的抗肿瘤治疗将作为极具潜力的方法而逐渐引起人们的重视。本文就近些年各种病毒在治疗结直肠癌中的研究进展做一综述。

Virus-based anti-tumor therapies are novel biological treatments. Viral vectors can infect tumors to kill cancers directly （on- colysis）, act as cancer vaccines to activate the immune system, and deliver genes with anti-tumor activity to the cancer cells. Genetic engineering has been applied to viruses to achieve more specific and efficient cancer treatment. Simultaneously, a reasonable combi- nation of viral vectors and existing anti-tumor therapy can improve the therapeutic effect. Consequently, virus-based therapy is expect- ed to serve as an effective anti-tumor strategy. We reviewed recent studies on the anti-tumor viral therapy of colorectal carcinoma.