从毒损心络理论探讨糖尿病心肌病发病机制及相关研究

The Pathogenesis of Diabetic Cardiomyopathy and Related Research from Theory of Injury of Heart and Collaterals due to Pathogenic Factors

根据毒损心络理论探讨糖尿病心肌病的中医病机,指出气阴两虚是糖尿病心肌病的发病基础,络脉瘀阻、饮凝痰聚是其主要病理过程,积久成毒,络息毒损为主要病理改变。依据"益气养阴、解毒通络"法制定的生脉解毒通络胶囊,对糖尿病心肌病心肌组织有明显保护作用,对细胞外基质及调控炎症因子方面有明显的影响。理论及实验研究初步阐明,络息毒损的病理改变与糖尿病心肌病细胞外基质产生及炎症因子高表达具有内在相关性,佐证了毒损心络理论的科学价值。

According to the theory of ＂ injury of heart and collaterals due to pathogenic factors＂, we discussed the pathogenesis of diabetic cardiomyopathy, and pointed out the deficiency of both qi and yin is the basic pathogenesis of diabetic cardiomyopathy, collateral stasis and phlegm coagulation of poly drink is the main pathological process, accumulated into poison, poison damage of collaterals is the main pathological change. On the basis of Shengmai Jiedu Tongluo capsule, the method that had significant protective effects on myocardium of diabetic cardiomyopathy, and had a significant effect on extracellular matrix and the regulation of inflammatory factors. Theory and experiment showed that the high expression of pathological changes of diabetic cardiomyopathy and extracellular matrix damage of collaterals and generation of inflammatory factors have correlation, and proved the scientific value of injury of heart and collaterals due to pathogenic factors.