Effect of Rho-ROCK signaling pathway on pulmonary fibrosis

Rho-ROCK信号通路在肺纤维化中的作用（英文）

Idiopathic pulmonary fibrosis（IPF） is characterized by progressive lung scarring, reduced median survival, poor prognosis and limited therapeutic options, leading to great need for new pharmacologic therapies. In recent years, researchers have found that Rho-ROCK signaling pathway may be a new drug target in the prevention of IPF. This article reviewed the role of Rho-ROCK pathway in pulmonary fibrosis and the application of ROCK inhibitors in experimental models of IPF. Multiple lines of evidence therefore indicated that ROCK inhibition has great potential to be a powerful therapeutic tool in the prevention and treatment of IPF in clinic.

特发性肺纤维化(Idiopathic pulmonary fibrosis,IPF)是一种以肺部渐进性结疤为病症的疾病,生存期短,预后不佳,目前的治疗选择非常有限。因此,发现IPF的新机制及关于针对此机制的新药研究,对改善IPF预后具有重要意义。近年来,不断深入的研究提示:Rho-ROCK信号通路可能成为防治IPF的药物新靶点。本文通过阐述Rho-ROCK信号通路在肺纤维化过程中的作用及其抑制剂在IPF动物模型中的应用,探讨Rho-ROCK作为抗肺纤维化药物的作用靶点的可能性,为临床上预防和治疗肺纤维化提供新的思路和策略。