肿瘤患者PICC相关静脉血栓形成时间及其影响因素

PICC-related venous thrombosis time in cancer patients and its influencing factors

目的探讨肿瘤患者经外周静脉穿刺中心静脉置管(peripherally inserted central venous catheters,PICC)相关静脉血栓形成时间及其影响因素。方法回顾2010年10月-2014年12月224例恶性肿瘤PICC患者的临床资料,分析肿瘤患者PICC相关静脉血栓形成的影响因素。结果发生PICC相关静脉血栓34例患者中,PICC相关静脉血栓形成时间(17.20±2.21)d。单因素与多因素分析显示,使用红系造血刺激剂、治疗剂量抗凝、PICC相关感染、住院、穿刺静脉及血小板计数是肿瘤患者PICC相关静脉血栓形成的危险因素。结论影响肿瘤患者PICC相关静脉血栓的因素较多,应采取综合措施降低肿瘤患者PICC相关静脉血栓发生率。

Objective To investigate the peripherally inserted central venous catheters（PICC）-related venous thrombosis time in cancer patients and its influencing factors.Methods A retrospective analysis of the clinical data of PICC placement of 224 patients with malignant tumors admitted to our hospital during October 2010 and December 2014 was conducted to find the influencing factors of PICC-related venous thrombosis in cancer patients.Results Among the 34 patients with venous thrombosis,the venous thrombosis time was（17.20 ± 2.21）d.Pearson univariate and multivariate logistic regression analysis showed that using ESA or therapeutic dose of anticoagulant,PICC-related infections,hospitalization,given veinpuncture and platelet count were risking factors of PICC-related venous thrombosis in cancer patients.Conclusion Quite a lot factors can lead to PICC-related venous thrombosis in cancer patients.Therefore,integrated measures should be taken to reduce rate of PICC related venous thrombosis.