探究血清前白蛋白与胆碱酯酶在肝病诊断中临床意义

Clinical significance of serum prealbumin(PA)and cholinesterase(CHE)in diagnosing liver diseases

[目的]探究与分析血清前蛋白（PA）与胆碱酯酶（CHE）在肝病诊断中的临床意义。[方法]选取我院自2013年5月~2015年5月收治的150例肝病患者作为试验组,另选取同时期收治的健康体检者150例作为对照组,采用日立7600生化分析仪对比2组人员血清前白蛋白（PA）与胆碱酯酶（CHE）水平进行分析,比较两者在肝病组和健康对照组间的差异。[结果]试验组血清PA及CHE的含量与对照组血清PA及CHE的含量分别相比均具有显著差异（t=10.45,P〈0.05;t=8.28,P〈0.05）。慢性肝炎中度、慢性肝炎重度、肝炎后肝硬化、肝癌的血清PA与对照组比较差异均有统计学意义（t=7.66,P〈0.05;t=8.34,P〈0.05;t=13.56,P〈0.05;t=9.12,P〈0.05）。慢性肝炎中度、慢性肝炎重度、肝炎后肝硬化血清CHE含量与对照组比较差异均有统计学意义（t=6.56,P〈0.05;t=8.78,P〈0.05;t=10.34,P〈0.05）。[结论]血清前白蛋白（PA）以及胆碱酯酶（CHE）变化能灵敏、快速反应肝病发生时,肝脏的损害程度,可作为一类诊断肝病的指标广泛应用并推广于临床工作中。

[Objective]To explore and analyse the clinical significance of serum protein（PA）and cholinesterase（CHE）in liver diseases＇ diagnosis.[Methods]From May 2013 to May 2013,150 cases of patients with liver diseases in our hospital were treated as experimental group,at the same time another 150 cases with healthy physical examination were treated as control group.Hitachi 7600 biochemical analyzer was used to compare the content of serum prealbumin（PA）and cholinesterase（CHE）levels in the two groups.[Results]The content of serum PA and CHE in the experimental group showed significant difference as compared with those in the control group（t=10.45,P〈0.05,t=0.05,P〈0.05）.The content of serum PA of moderate,chronic hepatitis,severe chronic hepatitis,liver cirrhosis after hepatitis,liver cancer had significant difference as compared with the control group（t=7.66,P〈0.05,t=0.05,P〈0.05,t=0.05,P〈0.05,t=0.05,P〈0.05）.The content of serum CHE of moderate,chronic hepatitis,severe chronic hepatitis,liver cirrhosis after hepatitis had significant difference as compared with the control group（t=6.56,P〈0.05,t=0.05,P〈0.05,t=0.05,P〈0.05）.[Conclusion]Changes of serum prealbumin（PA）and cholinesterase（CHE）can sensitively and rapidly reflect liver＇s damage when liver diseases occur,which may be used as indicators for diagnosis of liver diseases index and worth widely application and promotion in clinical work.