缓解期B系淋巴瘤患者外周血T细胞亚群检测

Peripheral blood T lymphocyte subsets of patients with B cell lymphoma in the stage of complete response

目的评估处于临床缓解期B系淋巴瘤患者的细胞免疫状态。方法应用流式细胞分析技术检测我院2010年11月至2014年7月处于临床缓解期的34例B系淋巴瘤患者外周血T细胞亚群。结果缓解期B系淋巴瘤患者外周血CD3^+、CD3^+CD4^+T淋巴细胞亚群及CD4^+/CD8^+均低于健康对照组(P<0.05);惰性B系淋巴瘤患者外周血CD3^+、CD3^+CD4^+、CD3^+CD56^+T淋巴细胞亚群及CD4^+/CD8^+均较侵袭性B系淋巴瘤患者高(P<0.05)。结论缓解期B系淋巴瘤患者仍存在细胞免疫功能低下,且侵袭性较惰性淋巴瘤免疫功能紊乱更严重。

Objective To assess the cellular immune function of patients with B cell lymphoma in the stage of complete response.Methods Totally 34 diagnosed B cell lymphoma in the stage of complete response from November 2010 to July 2014 were analyzed the peripheral blood T lymphocyte subsets by flow cytometry. Results The peripheral blood CD3~＋,CD4~＋T lymphocyte and CD4~＋/CD8~＋ ratios were lower in B cell lymphoma than in healthy control. The peripheral blood CD3~＋,CD3~＋CD4~＋,CD3~＋CD56~＋T lymphocyte and CD4~＋/ CD8~＋ ratios were higher in indolent lymphoma compared to invasive lymphoma. Conclusion Patients with B cell lymphoma in the stage of complete response were still in low cellular immune function,especially with invasive lymphoma.