CTRP-3水平和肥胖症的相关性研究

Correlation between CTRP-3 level and obesity

目的：研究补体C1q肿瘤坏死因子相关蛋白3（CTRP-3）在肥胖患者的表达及意义。方法：选择肥胖患者402例（肥胖组）和正常体检人员405例（正常对照组）。分析CTRP-3水平与有关指标的相关性,并利用多因素回归分析研究肥胖的独立危险因素。结果：与正常对照组相比,肥胖组人体质量指数（BMI）、收缩压（SBP）、舒张压（DBP）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）、空腹血糖（FBG）、胰岛素、稳态模型胰岛素抵抗指数（HOMA-IR）、糖化血红蛋白（HbA1c）、高敏C反应蛋白（hsCRP）水平均显著升高,而高密度脂蛋白胆固醇（HDL-C）、脂联素（APN）、瘦素和CTRP-3水平均显著降低,P〈0.05或〈0.01。Spearman相关分析显示,校正年龄、性别后,CTRP-3水平与BMI（r=-0.221）、SBP（r=-0.031）、DBP（r=-0.043）、TC（r=-0.147）、LDL-C（r=-0.051）、TG（r=-0.743）、FBG（r=-0.238）、胰岛素（r=-0.053）、HOMA-IR（r=-0.281）、HbA1c（r=-0.741）和hsCRP水平（r=-0.216）呈显著负相关（P〈0.05或〈0.01）,与HDL-C（r=0.351）、APN（r=0.852）和瘦素水平（r=0.641）呈显著正相关,P均〈0.05。多因素回归分析显示,在调整了其他影响因素后,与高三分位数CTRP-3组相比,中三分位数CTRP-3组OR值6.47（95%CI 3.58～12.18）和低三分位数CTRP-3组OR值12.39（95%CI 3.58～29.15）显著升高,P均〈0.01。结论：CTRP-3水平与肥胖相关因素显著相关,低CTRP-3水平是肥胖症的独立危险因素。

Objeettive： To study expression of complement Clq tumor necrosis factor related protein 3 （CTRP-3） in obese patients and its significance. Methods： A total of 402 obese patients were enrolled as obesity group and 405 normal people undergoing physical examination were regarded as normal control group. The correlation among CTRP-3 level and related indexes were analyzed, and multi- factor regression analysis was used to study independent risk factors for obesity. Results： Compared with normal control group, there were significant rise in body mass index （BMI）, homeostasis model - insulin resistance index （HOMA- IR）, levels of systolic blood pressure （SBP）, diastolic blood pressure （DBP）, total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C）, triglyceride （TG）, fasting blood glucose （FBG）, insulin, glycosylated hemoglobin （HbAlc） and high sensitive C reactive protein （hsCRP）, and significant reductions in levels of high density lipoprotein cholesterol （HI）L-C）, adiponectin （APN）, leptin and CTRP-3 in obesity group, P〈0.05 or 〈0. 01. Spearman correlation analysis indicated that after age and gender correction, CTRP-3 level was significant inversely correlated with BMI （r = - 0. 221）, SBP （r = - 0. 031）, DBP （r = - 0. 043）, TC （ r = - 0. 147）, LDL-C （r= -0.051）, TG（r= -0.743）, FBG （r= -0.238）, insulin （r= -0.053）, HOMA-IR （r= -0.281）, HbAlc （ r = - 0. 741） and hsCRP levels （ r = - 0. 216）, P〈0. 05 or 〈0.01, and significant positively correlated with lev- els of HDL-C （r = 0. 351）, APN （r = 0. 852） and leptin （r = 0. 641）, P〈0. 05 all. Multi- factor regression analysis indi- cated that after correcting other influencing factors, compared with high tertile CTRP-3 group, there were significant rise in OR value in middle tertile CTRP-3 group （OR= 6.47, 95%CI 3.58 - 12.18） and low tertile CTRP-3 group （OR= 12.39, 95%CI 3.58 - 29.15）, P〈0. 01 all. Conclusion： CTRP-3 level is significantly correlated with obesity- related fac- tors, and it＇s an independent risk factor for obesity.