左西孟旦、米力农和硝普钠治疗急性心力衰竭的对比研究

Comparative Efficacy of Levosimendan, Milrinone and Sodium Nitroprusside in Treatment of Acute Heart Failure

目的对比左西孟旦、米力农及硝普钠治疗急性心力衰竭的疗效。方法随机将123例急性心力衰竭患者分为左西孟旦组、米力农组、硝普钠组,观察治疗效果,比较治疗前后血清NT-pro BNP水平。结果治疗后,三组血清NT-pro BNP水平均低于治疗前,且左西孟旦组低于另外两组,左西孟旦组临床疗效高于另外两组,差异具有统计学意义(P<0.05)。结论临床治疗急性心力衰竭时,左西孟旦治疗效果优于米力农和硝普钠。

Objective Compare the curative effect of leosimendan, milrinone and sodium nitrate general in treatment of acute heart failure. Methods Selected 123 cases of acute heart failure patients were randomly divided into the leosimendan group, milrinone group, sodium nitroprusside group, compare before and after treatment serum level of NT-pro BNP. Results After treatment, the serum level of NT-pro BNP three group were lower than before the treatment, and the leosimendan group was lower than the other two groups, clinical curative effect of the leosimendan group was higher than the other two groups, the difference is statistically significant（P〈0.05）. Conclusion The clinical treatment of acute heart failure, leosimendan treatment effect is better than that of milrinone and sodium nitrate.